Multimodal fluorescently labeled polymer-coated GdF3 nanoparticles inhibit degranulation in mast cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F21%3A00548841" target="_blank" >RIV/68378271:_____/21:00548841 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/21:00548841 RIV/68378050:_____/21:00548841
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2021/NR/D1NR06127E" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2021/NR/D1NR06127E</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/D1NR06127E" target="_blank" >10.1039/D1NR06127E</a>
Alternative languages
Result language
angličtina
Original language name
Multimodal fluorescently labeled polymer-coated GdF3 nanoparticles inhibit degranulation in mast cells
Original language description
Multimodal gadolinium fluoride nanoparticles belong to potential contrast agents useful for bimodal optical fluorescence and magnetic resonance imaging. However, the metallic nature of the nanoparticles, similarly to some paramagnetic iron oxides, might induce allergic and anaphylactic reactions in patients after administration. A reduction of these adverse side effects is a priority for the safe application of the nanoparticles. Herein, we prepared paramagnetic poly(4-styrenesulfonic acid-co-maleic acid) (PSSMA)-stabilized GdF3 nanoparticles with surface modified by Atto 488-labeled poly(styrene-grad-2-dimethylaminoethyl acrylate)-block-poly(2-dimethylaminoethyl acrylate) (PSDA-A488) with reactive amino groups for introduction of an additional imaging (luminescence) modality and possible targeting of anticancer drugs. The saturation magnetization of GdF3@PSSMA particles according to SQUID magnetometry reached 157 Am2 kg−1 at 2 K and magnetic field of 7 T. GdF3@PSSMA-PSDA-A488 nanoparticles were well tolerated by human cervical adenocarcinoma (HeLa), mouse bone marrow-derived mast cells (BMMC), and rat basophilic mast cells (RBL-2H3), the particles also affected cell morphology and protein tyrosine phosphorylation in mast cells. Moreover, the nanoparticles interfered with the activation of mast cells by multivalent antigens and inhibited calcium mobilization and cell degranulation. These findings show that the new multimodal GdF3-based nanoparticles possess properties useful for various imaging methods and might minimize mast cell degranulation incurred after future nanoparticle diagnostic administration.n
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10302 - Condensed matter physics (including formerly solid state physics, supercond.)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
—
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nanoscale
ISSN
2040-3364
e-ISSN
2040-3372
Volume of the periodical
13
Issue of the periodical within the volume
45
Country of publishing house
GB - UNITED KINGDOM
Number of pages
15
Pages from-to
19023-19037
UT code for WoS article
000716549400001
EID of the result in the Scopus database
2-s2.0-85120378658