Influence of the pre-exposure of a Zn-0.8Mg-0.2Sr absorbable alloy in bovine serum albumin containing media on its surface changes and their impact on the cytocompatibility of the material

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F21%3A00549692" target="_blank" >RIV/68378271:_____/21:00549692 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22310/21:43922707 RIV/00216208:11110/21:10430535 RIV/00064165:_____/21:10430535

Result on the web

<a href="https://doi.org/10.1016/j.mtcomm.2021.102556" target="_blank" >https://doi.org/10.1016/j.mtcomm.2021.102556</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.mtcomm.2021.102556" target="_blank" >10.1016/j.mtcomm.2021.102556</a>

Result language

angličtina

Original language name

Influence of the pre-exposure of a Zn-0.8Mg-0.2Sr absorbable alloy in bovine serum albumin containing media on its surface changes and their impact on the cytocompatibility of the material

Original language description

n this study, the ternary alloy ZnMg0.8Sr0.2 (wt%) was pre-exposed in a phosphate buffer solution (PBS) with and without the addition of 1 wt% of bovine serum albumin (BSA) to simulate the early stage of the post- implantation period. We investigated the influence of the presence of BSA in the pre-exposure medium on surface chemistry, roughness topography and cytotoxicity of the pre-exposed materials. This study revealed that the pre-exposure in PBS with the addition of BSA induces the formation of a relatively thick and compact phosphate layer on the sample surface. In contrast, the majority of the surface of the samples pre-exposed in pure PBS appear almost untouched, and only a few small areas covered by eye-visible corrosion products were observed. This resulted in lower ion release (66 μmol/L) and a consequent decrease of the cytotoxicity of the eluates prepared from the samples pre-exposed in the BSA containing media. Together with the knowledge available from the literature, the obtained results indicate that BSA affects the degradation mechanism of the Zn- based alloy, resulting in the formation of zinc-BSA complexes. These complexes stimulate the precipitation of phosphates and a consequent formation of solid corrosion products with a protective function. This partially mimics the surface changes occurring in the early post-implantation period. The aforementioned suggests that a suitable pre-exposure of Zn-based absorbable materials in a protein containing media could be used as an approach to obtain reliable data about cytocompatibility by in vitro tests and reduce the discrepancies with the results obtained in vivo.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20506 - Coating and films

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Materials Today Communications

ISSN

2352-4928

e-ISSN

2352-4928

Volume of the periodical

28

Issue of the periodical within the volume

Sept.

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

13

Pages from-to

102556

UT code for WoS article

000697187300005

EID of the result in the Scopus database

2-s2.0-85111047283