Biological impact of target fragments on proton treatment plans: an analysis based on the current cross-section data and a full mixed field approach

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F21%3A00563526" target="_blank" >RIV/68378271:_____/21:00563526 - isvavai.cz</a>

Result on the web

<a href="https://hdl.handle.net/11104/0335476" target="_blank" >https://hdl.handle.net/11104/0335476</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cancers13194768" target="_blank" >10.3390/cancers13194768</a>

Result language

angličtina

Original language name

Biological impact of target fragments on proton treatment plans: an analysis based on the current cross-section data and a full mixed field approach

Original language description

Clinical routine in proton therapy currently neglects the radiobiological impact of nuclear target fragments generated by proton beams. This is partially due to the difficult characterization of the irradiation field. The detection of low energetic fragments, secondary protons and fragments, is in fact challenging due to their very short range. However, considering their low residual energy and therefore high LET, the possible contribution of such heavy particles to the overall biological effect could be not negligible. In this context, we performed a systematic analysis aimed at an explicit assessment of the RBE (relative biological effectiveness, i.e., the ratio of photon to proton physical dose needed to achieve the same biological effect) contribution of target fragments in the biological dose calculations of proton fields.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10305 - Fluids and plasma physics (including surface physics)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancers (Basel)

ISSN

2072-6694

e-ISSN

2072-6694

Volume of the periodical

13

Issue of the periodical within the volume

19

Country of publishing house

CH - SWITZERLAND

Number of pages

23

Pages from-to

4768

UT code for WoS article

000708183900001

EID of the result in the Scopus database

2-s2.0-85115651436