Characterization and insights into the formation of new multicomponent solid forms of sofosbuvir

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F22%3A00558650" target="_blank" >RIV/68378271:_____/22:00558650 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22310/22:43925021 RIV/60461373:22340/22:43925021
Result on the web
<a href="https://doi.org/10.1021/acs.cgd.2c00207" target="_blank" >https://doi.org/10.1021/acs.cgd.2c00207</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.cgd.2c00207" target="_blank" >10.1021/acs.cgd.2c00207</a>

Result language
angličtina
Original language name
Characterization and insights into the formation of new multicomponent solid forms of sofosbuvir
Original language description
Sofosbuvir, a drug used for the treatment of hepatitis C, is known to have several polymorphs. However, its ability to form multicomponent solid forms has been little researched, and only the crystal structure of one cocrystal has been reported until today. In this work, with the methods of slurry experiments, solution evaporation, and mechanochemistry, we synthesized three cocrystals, two solvates, and two coamorphous systems of sofosbuvir, for which we provide full characterization. Furthermore, we solved the crystal structures of the multicomponent solid forms of sofosbuvir with piperazine, di chloromethane, and chloroform, allowing us to investigate, compare, and discuss their molecular interaction energies.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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