DNA interaction and BSA binding of O-vanillin-based new Schiff base Co (III) and Ni(II) complexes: Theoretical, experimental, antibacterial and anticancer studies

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F22%3A00559840" target="_blank" >RIV/68378271:_____/22:00559840 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.poly.2022.115987" target="_blank" >https://doi.org/10.1016/j.poly.2022.115987</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.poly.2022.115987" target="_blank" >10.1016/j.poly.2022.115987</a>

Result language
angličtina
Original language name
DNA interaction and BSA binding of O-vanillin-based new Schiff base Co (III) and Ni(II) complexes: Theoretical, experimental, antibacterial and anticancer studies
Original language description
In the present work, two new mononuclear CoIII and NiII complexes containing H2valmea Schiff base ligand (H2valmea = 2-(((2-hydroxyethyl)imino)methyl)-6-methoxyphenol) were synthesized. X-ray crystallography, besides other techniques such as CHN, FT-IR and UV–Vis spectroscopy, determined the exact structures of both complexes. Bio-interactions (BSA and DNA binding), the antineoplastic ability and basal cell toxicity of complexes were investigated by various experimental and docking methods. Fluorescence emission and UV–Vis absorbance experiments confirmed the static mechanism in the interaction of both complexes with protein.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Project
<a href="/en/project/GA18-10504S" target="_blank" >GA18-10504S: Crystallography21 - New generation of universal tools for structure analysis from diffraction data</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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