Multimodal contrast agent enabling pH sensing based on organically functionalized gold nanoshells with Mn-Zn ferrite cores
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F22%3A00563784" target="_blank" >RIV/68378271:_____/22:00563784 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/22:10442306 RIV/60461373:22340/22:43923148 RIV/00216275:25310/22:39918981 RIV/00216208:11110/22:10442306 RIV/00216208:11320/22:10442306
Result on the web
<a href="https://hdl.handle.net/11104/0335589" target="_blank" >https://hdl.handle.net/11104/0335589</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/nano12030428" target="_blank" >10.3390/nano12030428</a>
Alternative languages
Result language
angličtina
Original language name
Multimodal contrast agent enabling pH sensing based on organically functionalized gold nanoshells with Mn-Zn ferrite cores
Original language description
Gold nanoshells with magnetic cores and complex organic functionalization may offer an efficient multimodal platform for MRI, photoacoustic imaging (PAI), and fluorescence techniques combined with pH sensing by SERS. In the present study, the synthesis of gold nanoshells with Mn-Zn ferrite cores is described, and their properties are analyzed by XRD, XRF, TEM, magnetic measurements, and UV-Vis spectroscopy. The gold surface is functionalized with four different model molecules to analyze the effect of varying charge and surface chemistry on cells in vitro. Finally, the nanoshells are functionalized with a combination of 4-mercaptobenzoic acid and 7-mercapto-4-methylcoumarin, which introduces a SERS active pH sensor and a covalently attached fluorescent tag. NMR relaxometry, fluorescence spectroscopy, and PAI demonstrate the multimodal potential of the suggested probe, including extraordinarily high transverse relaxivity, while the SERS study evidences a pH-dependent spectral response.n
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
21001 - Nano-materials (production and properties)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nanomaterials
ISSN
2079-4991
e-ISSN
2079-4991
Volume of the periodical
12
Issue of the periodical within the volume
3
Country of publishing house
CH - SWITZERLAND
Number of pages
23
Pages from-to
428
UT code for WoS article
000755646400001
EID of the result in the Scopus database
2-s2.0-85123434057