Intermittent F-actin perturbations by magnetic fields inhibit breast cancer metastasis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F23%3A00570700" target="_blank" >RIV/68378271:_____/23:00570700 - isvavai.cz</a>
Result on the web
<a href="https://hdl.handle.net/11104/0342024" target="_blank" >https://hdl.handle.net/11104/0342024</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.34133/research.0080" target="_blank" >10.34133/research.0080</a>
Alternative languages
Result language
angličtina
Original language name
Intermittent F-actin perturbations by magnetic fields inhibit breast cancer metastasis
Original language description
F-actin (filamentous actin) has been shown to be sensitive to mechanical stimuli and play critical roles in cell attachment, migration, and cancer metastasis, but there are very limited ways to perturb F-actin dynamics with low cell toxicity. Magnetic field is a noninvasive and reversible physical tool that can easily penetrate cells and human bodies. Here, we show that 0.1/0.4-T 4.2-Hz moderate-intensity low-frequency rotating magnetic field-induced electric field could directly decrease F-actin formation in vitro and in vivo, which results in decreased breast cancer cell migration, invasion, and attachment. Moreover, low- frequency rotating magnetic fields generated significantly different effects on F-actin in breast cancer vs. noncancerous cells, including F-actin number and their recovery after magnetic field retrieval.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10302 - Condensed matter physics (including formerly solid state physics, supercond.)
Result continuities
Project
<a href="/en/project/EF16_019%2F0000760" target="_blank" >EF16_019/0000760: Solid State Physics for 21st century</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Research
ISSN
2096-5168
e-ISSN
2639-5274
Volume of the periodical
6
Issue of the periodical within the volume
Mar
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
0080
UT code for WoS article
000931340200001
EID of the result in the Scopus database
2-s2.0-85152141551