Effects of gradient high-field static magnetic fields on diabetic mice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F23%3A00570706" target="_blank" >RIV/68378271:_____/23:00570706 - isvavai.cz</a>
Result on the web
<a href="https://hdl.handle.net/11104/0342031" target="_blank" >https://hdl.handle.net/11104/0342031</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.24272/j.issn.2095-8137.2022.460" target="_blank" >10.24272/j.issn.2095-8137.2022.460</a>
Alternative languages
Result language
angličtina
Original language name
Effects of gradient high-field static magnetic fields on diabetic mice
Original language description
Although 9.4 T magnetic resonance imaging (MRI) has been tested in healthy volunteers, its safety in diabetic patients is unclear. Furthermore, the effects of high static magnetic fields (SMFs), especially gradient vs. uniform fields, have not been investigated in diabetics. Here, we investigated the consequences of exposure to 1.0–9.4 T high SMFs of different gradients (>10 T/m vs. 0–10 T/m) on type 1 diabetic (T1D) and type 2 diabetic (T2D) mice. We found that 14 h of prolonged treatment of gradient (as high as 55.5 T/m) high SMFs (1.0–8.6 T) had negative effects on T1D and T2D mice, including spleen, hepatic, and renal tissue impairment and elevated glycosylated serum protein, blood glucose, inflammation, and anxiety, while 9.4 T quasi-uniform SMFs at 0–10 T/m did not induce the same effects. In regular T1D mice (blood glucose ≥16.7 mM), the >10 T/m gradient high SMFs increased malondialdehyde (P<0.01) and decreased superoxide dismutase (P<0.05).
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10302 - Condensed matter physics (including formerly solid state physics, supercond.)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ZOOLOGICAL RESEARCH
ISSN
2095-8137
e-ISSN
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Volume of the periodical
44
Issue of the periodical within the volume
2
Country of publishing house
CN - CHINA
Number of pages
10
Pages from-to
249-258
UT code for WoS article
000972105700001
EID of the result in the Scopus database
2-s2.0-85146411166