Scalable production of tissue-like vascularized liver organoids from human PSCs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F23%3A00576064" target="_blank" >RIV/68378271:_____/23:00576064 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/23:10469520
Result on the web
<a href="https://hdl.handle.net/11104/0346848" target="_blank" >https://hdl.handle.net/11104/0346848</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s12276-023-01074-1" target="_blank" >10.1038/s12276-023-01074-1</a>
Alternative languages
Result language
angličtina
Original language name
Scalable production of tissue-like vascularized liver organoids from human PSCs
Original language description
The lack of physiological parity between 2D cell culture and in vivo culture has led to the development of more organotypic models, such as organoids. Organoid models have been developed for a number of tissues, including the liver. Current organoid protocols are characterized by a reliance on extracellular matrices (ECMs), patterning in 2D culture, costly growth factors and a lack of cellular diversity, structure, and organization. Current hepatic organoid models are generally simplistic and composed of hepatocytes or cholangiocytes. We have developed an approach that does not require 2D patterning, is ECM independent, and employs small molecules to mimic embryonic liver development that produces large quantities of liver-like organoids. The organoids exhibit key liver functions, including drug metabolism, serum protein production, urea synthesis and coagulation factor production, with preserved post-translational modifications such as N-glycosylation and functionality.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Experimental and Molecular Medicine
ISSN
1226-3613
e-ISSN
2092-6413
Volume of the periodical
55
Issue of the periodical within the volume
9
Country of publishing house
KR - KOREA, REPUBLIC OF
Number of pages
20
Pages from-to
2005-2024
UT code for WoS article
001065142700006
EID of the result in the Scopus database
2-s2.0-85169166859