Synthesis of N3-substituted-quinazoline-2,4(1H/3H)-diones via CuI-catalyzed coupling of 2-iodobenzamides with potassium cyanate

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F25%3A00619022" target="_blank" >RIV/68378271:_____/25:00619022 - isvavai.cz</a>
Result on the web
<a href="https://hdl.handle.net/11104/0365788" target="_blank" >https://hdl.handle.net/11104/0365788</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.rechem.2025.102204" target="_blank" >10.1016/j.rechem.2025.102204</a>

Result language
angličtina
Original language name
Synthesis of N3-substituted-quinazoline-2,4(1H/3H)-diones via CuI-catalyzed coupling of 2-iodobenzamides with potassium cyanate
Original language description
Herein, we disclosed the synthesis of N3-substituted-quinazoline-2,4(1H,3H)-diones via the consecutive copper catalyzed coupling/annulation of 2-iodobenzamides and KOCN. This transformation is characterized by the in situ-generation of arylisocyante through C(sp2)-N(sp2) bond formation, which enriches the library of preparation quinazolindiones. Moreover, it is worth noting that replacing the iodo group with bromo also produced comparable yield of the corresponding quinazolinedione derived under the present conditions.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Project
<a href="/en/project/LM2023051" target="_blank" >LM2023051: Research infrastructure CzechNanoLab</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)