Anticancer drug design of potassium ion (K+) assisted self-assembled Cu(II) Schiff base complex and its Ni(II) and Zn(II) analogues (3d-4s): A comparative study of DNA/protein (BSA) interactions and cytotoxicity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F25%3A00619028" target="_blank" >RIV/68378271:_____/25:00619028 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.molstruc.2024.140940" target="_blank" >https://doi.org/10.1016/j.molstruc.2024.140940</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.molstruc.2024.140940" target="_blank" >10.1016/j.molstruc.2024.140940</a>

Result language
angličtina
Original language name
Anticancer drug design of potassium ion (K+) assisted self-assembled Cu(II) Schiff base complex and its Ni(II) and Zn(II) analogues (3d-4s): A comparative study of DNA/protein (BSA) interactions and cytotoxicity
Original language description
In the research for the therapeutic agents, three novel dinuclear 3d-4s complexes with a glycine-derived Schiff base ligand and a side-on bridging azido (μ-1,3-N3) ligand were synthesized and characterized, with formulas [K(CuL)(μ-1,3-N3)] (KCuL), [K(NiL)(μ-1,3-N3)] (KNiL) and [K(ZnL)(μ-1,3-N3)] (KZnL), where L indicates the Schiff base containing stoichiometric ratio of glycine and salicylaldehyde. Different structural, spectral and analytical methods, such as single-crystal X-ray crystallography, CHN analysis, FT-IR, UV–Vis and mass spectroscopy, were used for the characterization.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10302 - Condensed matter physics (including formerly solid state physics, supercond.)

Project
<a href="/en/project/LM2023051" target="_blank" >LM2023051: Research infrastructure CzechNanoLab</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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