Facile fabrication of large-area biofunctionalized metallic nanostructures for high performance affinity plasmonic biosensors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F25%3A00635551" target="_blank" >RIV/68378271:_____/25:00635551 - isvavai.cz</a>
Result on the web
<a href="https://hdl.handle.net/11104/0366613" target="_blank" >https://hdl.handle.net/11104/0366613</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/admt.202500356" target="_blank" >10.1002/admt.202500356</a>
Alternative languages
Result language
angličtina
Original language name
Facile fabrication of large-area biofunctionalized metallic nanostructures for high performance affinity plasmonic biosensors
Original language description
An approach is presented to the facile preparation of biointerface-caped periodic arrays of gold nanoparticles (Au NP) with controlled plasmonic and advanced sensing properties. It relies on feedback-controlled UV-laser interference lithography combined with a novel ion milling method. These advancements improved preparation reproducibility yielding localized surface plasmon resonance (LSPR) wavelength tuned to near infrared spectrum with standard deviation of 10 nm. Moreover, a novel molecular toolkit of thiols and silatrane linkers with carboxybetaine/sulfobetaine headgroups is employed for orthogonal chemical modification of Au NPs and passivation of the optically non-active sensor chip regions, to prevent non-specific sorption of molecules from liquid samples. As part of this toolbox, the use of mercaptopropyl silatrane is reported as an adhesion-promoting coating for attaching Au NPs to an oxide substrate, replacing the traditionally used strongly absorbing chromium. The developed biofunctional optical nanostructures show LSPR with improved quality factor and enable 2.5-fold increase in accuracy for tracking of biomolecular binding on their surface via LSPR wavelength variations monitoring. In addition, a strategy is demonstrated to mitigate unspecific biomolecule sorption not only at the plasmonic hotspot on the metal surface, but also on the often-overlooked oxide substrate, highlighting the importance of the described orthogonal modification.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10306 - Optics (including laser optics and quantum optics)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advanced Materials Technologies
ISSN
2365-709X
e-ISSN
2365-709X
Volume of the periodical
10
Issue of the periodical within the volume
16
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
e00356
UT code for WoS article
001490966000001
EID of the result in the Scopus database
2-s2.0-105005774815