Deformation response of polydimethylsiloxane substrates subjected to uniaxial quasi-static loading
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378297%3A_____%2F19%3A00505063" target="_blank" >RIV/68378297:_____/19:00505063 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/19:00074109
Result on the web
<a href="https://ojs.cvut.cz/ojs/index.php/APP/article/view/6032" target="_blank" >https://ojs.cvut.cz/ojs/index.php/APP/article/view/6032</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.14311/APP.2019.25.0079" target="_blank" >10.14311/APP.2019.25.0079</a>
Alternative languages
Result language
angličtina
Original language name
Deformation response of polydimethylsiloxane substrates subjected to uniaxial quasi-static loading
Original language description
To investigate cellular response of cardiomyocytes to substrate mechanics, biocompatible material with stiffness in physiological range is needed. PDMS based material is used for construction of microfluidic organ on chip devices for cell culture due to ease of device preparation, bonding, and possibility of surface functionalization. However it has stiffness orders of magnitude out of physiological range. Therefore, we adapted recently available protocol aiming to prepare substrates which offer stiffness in physiological range 5−100 kPa using various mixtures of Sylgard. An in-house developer loading device with single micron position tracking accuracy and sub-micron position sensitivity was adapted for this experimental campaign. All batches of the samples were subjected to uniaxial loading. During quasi-static experiment the samples were compressed to minimally 40% deformation. The results are represented in the form of stress-strain curves calculated from the acquired force and displacement data and elastic moduli are estimated.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
20501 - Materials engineering
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Acta Polytechnica CTU Proceedings
ISBN
978-80-01-06670-6
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
79-82
Publisher name
Czech Technical University in Prague
Place of publication
Praha
Event location
Telč
Event date
Jun 6, 2019
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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