Beta-Titanium Alloy Covered by Ferroelectric Coating-Physicochemical Properties and Human Osteoblast-Like Cell Response

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21220%2F21%3A00349107" target="_blank" >RIV/68407700:21220/21:00349107 - isvavai.cz</a>

Alternative codes found

RIV/68378271:_____/21:00541646 RIV/67985823:_____/21:00541646 RIV/00216208:11320/21:10429526

Result on the web

<a href="https://doi.org/10.3390/coatings11020210" target="_blank" >https://doi.org/10.3390/coatings11020210</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/coatings11020210" target="_blank" >10.3390/coatings11020210</a>

Result language

angličtina

Original language name

Beta-Titanium Alloy Covered by Ferroelectric Coating-Physicochemical Properties and Human Osteoblast-Like Cell Response

Original language description

Beta-titanium alloys are promising materials for bone implants due to their advantageous mechanical properties. For enhancing the interaction of bone cells with this perspective material, we developed a ferroelectric barium titanate (BaTiO3) coating on a Ti39Nb alloy by hydrothermal synthesis. This coating was analyzed by scanning electron and Raman microscopy, X-ray diffraction, piezoresponse force microscopy, X-ray photoelectron spectroscopy, nanoindentation, and roughness measurement. Leaching experiments in a saline solution revealed that Ba is released from the coating. A progressive decrease of Ba concentration in the material was also found after 1, 3, and 7 days of cultivation of human osteoblast-like Saos-2 cells. On day 1, the Saos-2 cells adhered on the BaTiO3 film in higher initial numbers than on the bare alloy, but they were less spread, and their initial proliferation rate was slower. These cells also contained a lower amount of beta(1)-integrins and vinculin, i.e., molecules involved in cell adhesion, and produced a lower amount of collagen I. This cell behavior was attributed to a higher surface roughness of BaTiO3 film rather than to its potential cytotoxicity, because the cell viability on this film was very high, reaching almost 99%. The amount of alkaline phosphatase, an enzyme involved in bone matrix mineralization, was similar in cells on the BaTiO3-coated and uncoated alloy, and on day 7, the cells on BaTiO3 film attained a higher final cell population density. These results indicate that after some improvements, particularly in its roughness and stability, the hydrothermal ferroelectric BaTiO3 film could be promising coating for improved osseointegration of bone implants.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

20506 - Coating and films

Project

<a href="/en/project/GA20-01570S" target="_blank" >GA20-01570S: Improved osseointegration of bone implants with the use of ferroelectric coatings</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Coatings

ISSN

2079-6412

e-ISSN

2079-6412

Volume of the periodical

11

Issue of the periodical within the volume

2

Country of publishing house

CH - SWITZERLAND

Number of pages

23

Pages from-to

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UT code for WoS article

000622376700001

EID of the result in the Scopus database

2-s2.0-85100950917