Biomechanics of Arteriovenous Fistula: An Overview of Hemodynamic and Remodeling Mechanisms
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21220%2F25%3A00387687" target="_blank" >RIV/68407700:21220/25:00387687 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.14712/18059694.2025.25" target="_blank" >https://doi.org/10.14712/18059694.2025.25</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.14712/18059694.2025.25" target="_blank" >10.14712/18059694.2025.25</a>
Alternative languages
Result language
angličtina
Original language name
Biomechanics of Arteriovenous Fistula: An Overview of Hemodynamic and Remodeling Mechanisms
Original language description
Arteriovenous fistulas (AVFs) are widely accepted as the gold standard for vascular access in chronic hemodialysis patients due to their superior long-term patency and low complication rates. However, up to half of all created AVFs fail to mature adequately, and many develop late complications such as stenosis, thrombosis, or aneurysmal degeneration. This review provides an overview of the AVF development process, focusing on the biomechanical forces that drive vascular remodeling and contribute to maturation and pathological changes. We summarize the role of endothelial mechanotransduction and insights from recent studies that reveal how wall shear stress (WSS) patterns and oscillatory flow relate to the genesis of neointimal hyperplasia and later stenosis. Understanding these mechanobiological processes has led to novel surgical techniques, anastomosis design optimization, and better cannulation strategies. Although the knowledge of hemodynamic-biological interactions remain limited, further research can offer directions for better AVF performance.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
20302 - Applied mechanics
Result continuities
Project
<a href="/en/project/GA24-10597S" target="_blank" >GA24-10597S: Biomechanics of arteriovenous fistula aneurysms</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta medica (Hradec Kralove)
ISSN
1805-9694
e-ISSN
1805-9694
Volume of the periodical
68
Issue of the periodical within the volume
3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
5
Pages from-to
82-86
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-105026639251