Depth Recording Capabilities of Planar High-Density Microelectrode Arrays

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F09%3A00157920" target="_blank" >RIV/68407700:21230/09:00157920 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Depth Recording Capabilities of Planar High-Density Microelectrode Arrays
Original language description
We use a planar, CMOS-based microelectrode array (MEA) featuring 3,150 metal electrodes per mm2 and 126 recording channels to record spatially highly resolved extracellular action potentials (EAPs) from Purkinje cells (PCs) in acute cerebellar slices. AnIndependent-Component-Analysis-based (ICA) spike sorter is used to reveal EAPs of single cells at subcellular resolution. Those EAPs are then used to set up a compartment model of a PC. The model is used to make and finetune estimations of the distancebetween MEA surface and PC soma. This distance is estimated using the amplitude-independent part of the shape of the EAPs obtained from recordings. The estimation shows that, in our preparations, we can record from PCs with the center of their soma at approximately 35 ?m and 90 ?m vertical distance to the chip surface.
Czech name
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Czech description
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Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Proceedings of the 4th International IEEE EMBS Conference on Neural Engineering
ISBN
978-1-4244-2073-5
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
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Publisher name
IEEE
Place of publication
Piscataway
Event location
Antalya
Event date
Apr 29, 2009
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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