Targeting mitochondria for cancer treatment - two types of mitochondrial dysfunction

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F14%3A00310174" target="_blank" >RIV/68407700:21230/14:00310174 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21460/14:00310174

Result on the web

<a href="http://dx.doi.org/10.14712/23362936.2014.41" target="_blank" >http://dx.doi.org/10.14712/23362936.2014.41</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14712/23362936.2014.41" target="_blank" >10.14712/23362936.2014.41</a>

Result language

angličtina

Original language name

Targeting mitochondria for cancer treatment - two types of mitochondrial dysfunction

Original language description

Two basic types of cancers were identified &amp;#x2013; those with the mitochondrial dysfunction in cancer cells (the Warburg effect) or in fibroblasts supplying energy rich metabolites to a cancer cell with functional mitochondria (the reverse Warburg effect). Inner membrane potential of the functional and dysfunctional mitochondria measured by fluorescent dyes (e.g. by Rhodamine 123) displays low and high values (apparent potential), respectively, which is in contrast to the level of oxidative metabolism. Mitochondrial dysfunction (full function) results in reduced (high) oxidative metabolism, low (high) real membrane potential, a simple layer (two layers) of transported protons around mitochondria, and high (low) damping of microtubule electric polar vibrations. Crucial modifications are caused by ordered water layer (exclusion zone). For the high oxidative metabolism one proton layer is at the mitochondrial membrane and the other at the outer rim of the ordered water layer. High and low damping of electric polar vibrations results in decreased and increased electromagnetic activity in cancer cells with the normal and the reverse Warburg effect, respectively. Due to nonlinear properties the electromagnetic frequency spectra of cancer cells and transformed fibroblasts are shifted in directions corresponding to their power deviations resulting in disturbances of interactions and escape from tissue control. The cancer cells and fibroblasts of the reverse Warburg effect tumors display frequency shifts in mutually opposite directions resulting in early generalization. High oxidative metabolism conditions high aggressiveness. Mitochondrial dysfunction, a gate to malignancy along the cancer transformation pathway, forms a narrow neck which could be convenient for cancer treatment.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FS - Medical facilities, apparatus and equipment

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Prague Medical Report

ISSN

1214-6994

e-ISSN

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Volume of the periodical

115

Issue of the periodical within the volume

3-4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

16

Pages from-to

104-119

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-84929940097