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Aberrant expression of miRNA cluster in 14q32 region is associated with del(5q) myelodysplastic syndrome and lenalidomide treatment

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F15%3A00227293" target="_blank" >RIV/68407700:21230/15:00227293 - isvavai.cz</a>

  • Result on the web

    <a href="http://www.sciencedirect.com/science/article/pii/S2210776215000344" target="_blank" >http://www.sciencedirect.com/science/article/pii/S2210776215000344</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.cancergen.2015.03.003" target="_blank" >10.1016/j.cancergen.2015.03.003</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Aberrant expression of miRNA cluster in 14q32 region is associated with del(5q) myelodysplastic syndrome and lenalidomide treatment

  • Original language description

    BACKGROUND: Lenalidomide is a novel thalidomide analog with immunomodulatory and antiangiogenic effects that has been successfully used for the treatment of low- and intermediate-1 risk myelodysplastic syndromes (MDS) with a del(5q) aberration. METHODS:Because information about the influence of lenalidomide on the miRNA transcriptome is limited, we performed miRNA expression profiling of bone marrow CD34+ cells obtained from MDS patients with del(5q) abnormality who had been subjected to lenalidomide treatment. To define differences in miRNA expression, we performed paired data analysis to compare the miRNA profiles of patients before and during lenalidomide treatment and those of healthy donors. RESULTS: The analysis showed that miRNAs clustering tothe 14q32 region had a higher expression level in patient samples before treatment than in the healthy control samples, and this elevated expression was diminished following lenalidomide administration. CONCLUSION: Because some of the 14q

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Cancer Genetics

  • ISSN

    2210-7762

  • e-ISSN

  • Volume of the periodical

    208

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    6

  • Pages from-to

    156-161

  • UT code for WoS article

    000354911400009

  • EID of the result in the Scopus database

    2-s2.0-84929294768