Aberrant expression of miRNA cluster in 14q32 region is associated with del(5q) myelodysplastic syndrome and lenalidomide treatment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F15%3A00227293" target="_blank" >RIV/68407700:21230/15:00227293 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S2210776215000344" target="_blank" >http://www.sciencedirect.com/science/article/pii/S2210776215000344</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cancergen.2015.03.003" target="_blank" >10.1016/j.cancergen.2015.03.003</a>
Alternative languages
Result language
angličtina
Original language name
Aberrant expression of miRNA cluster in 14q32 region is associated with del(5q) myelodysplastic syndrome and lenalidomide treatment
Original language description
BACKGROUND: Lenalidomide is a novel thalidomide analog with immunomodulatory and antiangiogenic effects that has been successfully used for the treatment of low- and intermediate-1 risk myelodysplastic syndromes (MDS) with a del(5q) aberration. METHODS:Because information about the influence of lenalidomide on the miRNA transcriptome is limited, we performed miRNA expression profiling of bone marrow CD34+ cells obtained from MDS patients with del(5q) abnormality who had been subjected to lenalidomide treatment. To define differences in miRNA expression, we performed paired data analysis to compare the miRNA profiles of patients before and during lenalidomide treatment and those of healthy donors. RESULTS: The analysis showed that miRNAs clustering tothe 14q32 region had a higher expression level in patient samples before treatment than in the healthy control samples, and this elevated expression was diminished following lenalidomide administration. CONCLUSION: Because some of the 14q
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancer Genetics
ISSN
2210-7762
e-ISSN
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Volume of the periodical
208
Issue of the periodical within the volume
4
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
6
Pages from-to
156-161
UT code for WoS article
000354911400009
EID of the result in the Scopus database
2-s2.0-84929294768