Interaction-Based Aggregation of mRNA and miRNA Expression Profiles to Differentiate Myelodysplastic Syndrome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F15%3A00237846" target="_blank" >RIV/68407700:21230/15:00237846 - isvavai.cz</a>
Result on the web
<a href="http://link.springer.com/chapter/10.1007%2F978-3-319-26129-4_11" target="_blank" >http://link.springer.com/chapter/10.1007%2F978-3-319-26129-4_11</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-319-26129-4_11" target="_blank" >10.1007/978-3-319-26129-4_11</a>
Alternative languages
Result language
angličtina
Original language name
Interaction-Based Aggregation of mRNA and miRNA Expression Profiles to Differentiate Myelodysplastic Syndrome
Original language description
In this work we integrate conventional mRNA expression profiles with miRNA expressions using the knowledge of their validated or predicted interactions in order to improve class prediction in genetically determined diseases. The raw mRNA and miRNA expression features become enriched or replaced by new aggregated features that model the mRNA-miRNA interaction. The proposed subtractive integration method is directly motivated by the inhibition/degradation models of gene expression regulation. The method aggregates mRNA and miRNA expressions by subtracting a proportion of miRNA expression values from their respective target mRNAs. Further, its modification based on singular value decomposition that enables different subtractive weights for different miRNAs is introduced. Both the methods are used to model the outcome or development of myelodysplastic syndrome, a blood cell production disease often progressing to leukemia. The reached results demonstrate that the integration improves classification performance when dealing with mRNA and miRNA features of comparable significance. The proposed methods are available as a part of the web tool miXGENE.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
JC - Computer hardware and software
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Biomedical Engineering Systems and Technologies: Communications in Computer and Information Science
ISBN
978-3-319-26128-7
ISSN
1865-0929
e-ISSN
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Number of pages
16
Pages from-to
165-180
Publisher name
Springer
Place of publication
Heidelberg
Event location
Angers
Event date
Mar 3, 2014
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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