Sensitivity of microwave ablation models to tissue biophysical properties: A first step toward probabilistic modeling and treatment planning.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F16%3A00242811" target="_blank" >RIV/68407700:21230/16:00242811 - isvavai.cz</a>

Result on the web

<a href="http://scitation.aip.org/content/aapm/journal/medphys/43/5/10.1118/1.4947482" target="_blank" >http://scitation.aip.org/content/aapm/journal/medphys/43/5/10.1118/1.4947482</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1118/1.4947482" target="_blank" >10.1118/1.4947482</a>

Result language

angličtina

Original language name

Sensitivity of microwave ablation models to tissue biophysical properties: A first step toward probabilistic modeling and treatment planning.

Original language description

Computational models of microwave ablation are widely used during the design optimization of novel devices and are under consideration for patient-specific treatment planning. The objective of this study was to assess the sensitivity of computational models to tissue biophysical properties. The Morris method was employed to assess the global sensitivity of the coupled EM model, which was implemented with the finite element method (FEM). The FEM model incorporated temperature dependencies of tissue physical properties. Furthermore, the sensitivity results were statistically analyzed and absolute influence of each input parameter was quantified. A framework for systematically incorporating model uncertainties for treatment planning was suggested. Tissue dielectric parameters, specifically relative permittivity, effective conductivity, and the threshold temperature at which they transitioned to lower values, were identified as the most influential parameters for the shape of the ablation zone and antenna impedance matching. Of the thermal parameters considered in this study, the nominal blood perfusion rate and the temperature interval across which the tissue changes phase were identified as the most influential. The latent heat of tissue water vaporization and the volumetric heat capacity of the vaporized tissue were recognized as the least influential parameters. Based on the evaluation of absolute changes, the most important parameter (perfusion) had approximately 40.23 times greater influence on ablation area than the least important parameter (volumetric heat capacity of vaporized tissue). Another significant input parameter (permittivity) had 22.26 times higher influence on the deviation of ablation edge shape from a sphere than one of the less important parameters (latent heat of liver tissue vaporization).

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

JC - Computer hardware and software

OECD FORD branch

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Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Medical Physics

ISSN

0094-2405

e-ISSN

—

Volume of the periodical

2016(43)

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

13

Pages from-to

2649-2661

UT code for WoS article

000378924200063

EID of the result in the Scopus database

2-s2.0-84973639336