Hoarseness can be found in vocalisations of both human as well as genetically modified minipig model of huntington’s disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F16%3A00303523" target="_blank" >RIV/68407700:21230/16:00303523 - isvavai.cz</a>

Result on the web

<a href="http://jnnp.bmj.com/content/87/Suppl_1/A32.2.abstract?sid=d7f9c6e4-1eee-494d-b7eb-c8baef0b2efd" target="_blank" >http://jnnp.bmj.com/content/87/Suppl_1/A32.2.abstract?sid=d7f9c6e4-1eee-494d-b7eb-c8baef0b2efd</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1136/jnnp-2016-314597.96" target="_blank" >10.1136/jnnp-2016-314597.96</a>

Result language

angličtina

Original language name

Hoarseness can be found in vocalisations of both human as well as genetically modified minipig model of huntington’s disease

Original language description

Background: Voice quality of patients with Huntington’s disease is commonly perceived as harsh, hoarse, or breathy. Digital signal analysis allows to quantify the degree of hoarseness objectively by harmonic-to-noise ratio. Such a simple automated acoustic measurement could provide cheap, non-invasive, and effective biomarker of Huntington’s disease. Aims: The aim of this study is to explore, whether the hoarseness is presented in human as well as in a genetically modified minipig animal model of Huntington’s disease. Methods: Data were digitally recorded using head-set microphone with linear frequency response. Sustained phonations of the vowel/a/and vowel/i/were recorded from 20 patients with Huntington’s disease (mean duration of disease 6.4 years, standard deviation 3.0 years) and 23 matched healthy controls. Vocalisations were acquired from 14 Huntington’s disease transgenic minipigs (mean age 45.9 months, standard deviation 14.5 months), and 12 matched healthy siblings. Harmonic-to-noise ratio was analysed only on voiced segments of phonations and grunt-like vocalisations. Results: Harmonic-to-noise ratio was significantly decreased between patients with Huntington’s disease (mean 19.3 dB, standard deviation 5.4 dB) when compared to healthy control speakers (mean 22.4 dB, standard deviation 3.1 dB) (p < 0.05) as well as between transgenic minipigs (mean 3.26 dB, standard deviation 1.9 dB) as compared to healthy siblings (mean 4.3 dB, standard deviation 1.3 dB) (p < 0.05). Conclusions: Our results demonstrate that hoarseness is presented in both human as well as animal pig model of Huntington’s disease. Although dissimilarities of vocal apparatus between human and minipig are obvious, our findings suggest that pathophysiology mechanisms of Huntington’s disease influence voice in both human and minipig model similarly. More complex vocal assessment may be beneficial for monitoring of Huntington’s disease onset in transgenic minipigs.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

JA - Electronics and optoelectronics

OECD FORD branch

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Project

<a href="/en/project/NV15-28038A" target="_blank" >NV15-28038A: Speech disorders and analysis of their mechanisms in Parkinson's disease and other movement disorders.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů