Connectivity changes in epileptic network at the seizure onset
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F16%3A00304661" target="_blank" >RIV/68407700:21230/16:00304661 - isvavai.cz</a>
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1111/epi.13609/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/epi.13609/epdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/epi.13609" target="_blank" >10.1111/epi.13609</a>
Alternative languages
Result language
angličtina
Original language name
Connectivity changes in epileptic network at the seizure onset
Original language description
Purpose: Interaction between seizure onset zone (SOZ) and remaining epileptic network is still unclear. Recent studies have demonstrated dynamical reconfiguration of functional network connectivity at the seizure onset, particularly within the SOZ, but with inconsistent results. Method: In this study we explored the effective connectivity changes in intracranial EEG recordings from eight patients with refractory neocortical epilepsy. The detailed connectivity was represented by direct Directed Transfer Function (dDTF) that was optimized for short-time high-frequency resolution to analyse 36 seizures. Dynamics of the connectivity was tested between the whole SOZ and surrounding network (global view) and also between pairs of contacts within zones (local view) in the first seconds before and after seizure onset. Results: High specific decrease in effective connectivity in frequency range around 50-150 Hz was revealed in SOZ during early seizure states. However, common increase in energy and decrease in coherency reflected activation of the SOZ, not the disconnection from surrounding network. The high-amplitude propagated activity was observed in frequencies up to 100 Hz without connectivity changes. Conclusion: The presented results suggest that SOZ is characterized by activation of SOZ, predominantly in 50-150 Hz range, and this is characterised by decrease in connectivity. In addition the changes of the global connectivity in transition from pre-ictal to ictal state were highly specific marker for SOZ localization.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
JA - Electronics and optoelectronics
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů