HIGH-FREQUENCY OSCILLATION ABILITY TO LOCALIZE EPILEPTOGENIC TISSUE IN ANIMAL EPILEPSY MODEL

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F16%3A00305030" target="_blank" >RIV/68407700:21230/16:00305030 - isvavai.cz</a>

Result on the web

<a href="http://onlinelibrary.wiley.com/doi/10.1111/epi.13609/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/epi.13609/epdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/epi.13609" target="_blank" >10.1111/epi.13609</a>

Result language

angličtina

Original language name

HIGH-FREQUENCY OSCILLATION ABILITY TO LOCALIZE EPILEPTOGENIC TISSUE IN ANIMAL EPILEPSY MODEL

Original language description

Purpose: Recently, high-frequency oscillations (HFOs) have been reported to be a specific marker of the epileptogenic tissue. According to these findings, we explored the HFOs ability to localize epileptogenic lesion in the tetanus toxin model of epilepsy in the rat. To test this ability, we analyzed multi-channel intracranial electroencephalograms (iEEG) recorded in the epileptic animals. Methods: Four adult male rats (Wistar) were implanted bipolar macro-electrodes into the limbic structures, treated by the tetanus toxin injected in the CA3 area of the right dorsal hippocampus and long-term monitored. Overall 880 (4 9 220) min of iEEG were processed by the automatic HFO detector and further analyzed. The dominant frequency of HFOs was determined from the spectrogram and the occurrence of ipsilateral and contralateral events was compared for each subject separately. Furthermore, we examined the occurrence of ripples (Rip, 80–250 Hz) and fast ripples (FR, 250– 800 Hz) within ipsilateral structures. Results: The predominant occurrence of HFOs corresponds with the laterality of the epileptic focus in 3 of 4 subjects. The most active region in the ipsilateral hemisphere of all subjects was the ventral hippocampus, according to the ripple occurrence. The occurrence of FRs varies between subjects. The unique subject which demonstrate the anomalous pattern differed also with the significantly higher incidence of the high frequency events without any apparent cause. Conclusion: In most cases, the HFOs could be used to identify the laterality of the epileptic focus. The findings suggests the frequency of ripple occurrence in the long-term recordings points to the injected structure in all of examined animals. Similar result was expected also with FRs but was not confirmed. Another conclusion is, that the structures which do not express any HFO activity do not need to be considered a possible location of epileptic focus in further evaluation.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

JA - Electronics and optoelectronics

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů