Seizure clustering in tetanus toxin model of epilepsy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F19%3A00333020" target="_blank" >RIV/68407700:21230/19:00333020 - isvavai.cz</a>

Result on the web

<a href="http://www.exeter.ac.uk/media/universityofexeter/livingsystems/images/Abstract_Book.pdf" target="_blank" >http://www.exeter.ac.uk/media/universityofexeter/livingsystems/images/Abstract_Book.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Seizure clustering in tetanus toxin model of epilepsy

Original language description

Introduction: The long-term fluctuations in seizure probability and seizure clustering were multiple times reported in both patients and animal models of epilepsy including the tetanus toxin model in rats. The aim of this study was to explore the mechanisms which govern cluster progression and cluster onset. Results: We analyzed one seizure cluster in each animal. Clusters lasted 2.3±0.2 days and contained 90±15 seizures. All clusters were characterized by progressive increase of ISI. The percentage of convulsive seizures progressively increased in all clusters (p=0.008) and so did the signal power in the motor cortices (p=0.008) whereas in the hippocampi a non-significant decrease of power was observed (p=0.74). Between the clusters, we observed increasing rate, power and spread of epileptic bursts whereas the duration produced a U-shape. Conclusion: We have shown that during and between the clusters, the brain undergoes complex changes. We hypothesize that early non-convulsive seizures facilitate spreading of later seizures. In contrast, later generalized seizures have inhibitory effect which leads to reduction of seizure rate and finally to the cluster termination. Between the clusters, changes of the epileptic burst can be interpreted as increase of excitability and delayed recovery from internal perturbations which may serve as an early warning signal of impending transition to the next seizure cluster.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/NV17-28427A" target="_blank" >NV17-28427A: Functional and structural reorganization of brain networks after stroke: implications for diagnosis and therapy of associated comorbidities.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů