Directional microwave ablation: Experimental evaluation of a 2.45 GHz applicator in ex vivo and in vivo liver

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F20%3A00339323" target="_blank" >RIV/68407700:21230/20:00339323 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1016/j.jvir.2020.01.016" target="_blank" >https://doi.org/10.1016/j.jvir.2020.01.016</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jvir.2020.01.016" target="_blank" >10.1016/j.jvir.2020.01.016</a>

Result language

angličtina

Original language name

Directional microwave ablation: Experimental evaluation of a 2.45 GHz applicator in ex vivo and in vivo liver

Original language description

Purpose To experimentally characterize a microwave (MW) ablation applicator designed to produce directional ablation zones. Materials and Methods Using a 14-gauge, 2.45-GHz side-firing MW ablation applicator, 36 ex vivo bovine liver ablations were performed. Ablations were performed at 60 W, 80 W, and 100 W for 3, 5, and 10 minutes (n = 4 per combination). Ablation zone forward and backward depth and width were measured and directivity was calculated as the ratio of forward to backward depth. Thirteen in vivo ablations were performed in 2 domestic swine with the applicator either inserted into the liver (80 W, 5 min, n = 3; 100 W, 5 min, n = 3; 100 W, 10 min, n = 2) or placed on the surface of the liver with a nontarget tissue placed on the back side of the applicator (80 W, 5 min, n = 5). The animals were immediately euthanized after the procedure; the livers were harvested and sectioned perpendicular to the axis of the applicator. In vivo ablation zones were measured following viability staining and assessed on histopathology. Results Mean ex vivo ablation forward depth was 8.3–15.5 mm. No backward heating was observed at 60 W, 3–5 minutes; directivity was 4.7–11.0 for the other power and time combinations. In vivo ablation forward depth was 10.3–11.5 mm, and directivity was 11.5–16.1. No visible or microscopic thermal damage to nontarget tissues in direct contact with the back side of the applicator was observed. Conclusions The side-firing MW ablation applicator can create directional ablation zones in ex vivo and in vivo tissues.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20601 - Medical engineering

Project

<a href="/en/project/EF16_019%2F0000765" target="_blank" >EF16_019/0000765: Research Center for Informatics</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Vascular and Interventional Radiology

ISSN

1051-0443

e-ISSN

1535-7732

Volume of the periodical

31

Issue of the periodical within the volume

7

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

1170-1177

UT code for WoS article

000542580500024

EID of the result in the Scopus database

2-s2.0-85081926413