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Bronchoscopically delivered microwave ablation in an in vivo porcine lung model

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F20%3A00341923" target="_blank" >RIV/68407700:21230/20:00341923 - isvavai.cz</a>

  • Result on the web

    <a href="https://doi.org/10.1183/23120541.00146-2020" target="_blank" >https://doi.org/10.1183/23120541.00146-2020</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1183/23120541.00146-2020" target="_blank" >10.1183/23120541.00146-2020</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Bronchoscopically delivered microwave ablation in an in vivo porcine lung model

  • Original language description

    Background: Percutaneous microwave ablation is clinically used for inoperable lung tumor treatment. Delivery of microwave ablation applicators to tumor sites within lung parenchyma under virtual bronchoscopy guidance may enable ablation with reduced risk of pneumothorax providing a minimally-invasive treatment of early-stage tumors, which are increasingly detected with CT screening. Objectives: The objective of this study was to integrate a custom microwave ablation platform, incorporating a flexible applicator, with a clinically-established virtual bronchoscopy guidance system, and assess technical feasibility for safely creating localized thermal ablations in porcine lungs in vivo. Methods: Pre-ablation CTs of normal pigs were acquired to create a virtual model of the lungs, including airways and significant blood vessels. Virtual bronchoscopy guided microwave ablation procedures were performed with 24–32 W power (at the applicator distal tip) delivered for 5–10 mins. A total of 8 ablations were performed in 3 pigs. Post-treatment CT images were acquired to assess the extent of damage and ablation zones were further evaluated with viability stains and histopathologic analysis. Results: The flexible microwave applicators were delivered to ablation sites within lung parenchyma 5–24 mm from the airway wall via a tunnel created under virtual bronchoscopy guidance. No pneumothorax or significant airway bleeding were observed. The ablation short axis observed on gross pathology ranged between 16.5–23.5 mm and 14–26 mm on CT imaging. Conclusion: We have demonstrated the technical feasibility for safely delivering microwave ablation in the lung parenchyma under virtual bronchoscopic guidance in an in vivo porcine lung model.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>ost</sub> - Miscellaneous article in a specialist periodical

  • CEP classification

  • OECD FORD branch

    20601 - Medical engineering

Result continuities

  • Project

    <a href="/en/project/EF16_019%2F0000765" target="_blank" >EF16_019/0000765: Research Center for Informatics</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    European Respiratory Journal Open Research

  • ISSN

    2312-0541

  • e-ISSN

    2312-0541

  • Volume of the periodical

    6

  • Issue of the periodical within the volume

    10

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    11

  • Pages from-to

  • UT code for WoS article

    000603682700025

  • EID of the result in the Scopus database