Bronchoscopically delivered microwave ablation in an in vivo porcine lung model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F20%3A00341923" target="_blank" >RIV/68407700:21230/20:00341923 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1183/23120541.00146-2020" target="_blank" >https://doi.org/10.1183/23120541.00146-2020</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1183/23120541.00146-2020" target="_blank" >10.1183/23120541.00146-2020</a>
Alternative languages
Result language
angličtina
Original language name
Bronchoscopically delivered microwave ablation in an in vivo porcine lung model
Original language description
Background: Percutaneous microwave ablation is clinically used for inoperable lung tumor treatment. Delivery of microwave ablation applicators to tumor sites within lung parenchyma under virtual bronchoscopy guidance may enable ablation with reduced risk of pneumothorax providing a minimally-invasive treatment of early-stage tumors, which are increasingly detected with CT screening. Objectives: The objective of this study was to integrate a custom microwave ablation platform, incorporating a flexible applicator, with a clinically-established virtual bronchoscopy guidance system, and assess technical feasibility for safely creating localized thermal ablations in porcine lungs in vivo. Methods: Pre-ablation CTs of normal pigs were acquired to create a virtual model of the lungs, including airways and significant blood vessels. Virtual bronchoscopy guided microwave ablation procedures were performed with 24–32 W power (at the applicator distal tip) delivered for 5–10 mins. A total of 8 ablations were performed in 3 pigs. Post-treatment CT images were acquired to assess the extent of damage and ablation zones were further evaluated with viability stains and histopathologic analysis. Results: The flexible microwave applicators were delivered to ablation sites within lung parenchyma 5–24 mm from the airway wall via a tunnel created under virtual bronchoscopy guidance. No pneumothorax or significant airway bleeding were observed. The ablation short axis observed on gross pathology ranged between 16.5–23.5 mm and 14–26 mm on CT imaging. Conclusion: We have demonstrated the technical feasibility for safely delivering microwave ablation in the lung parenchyma under virtual bronchoscopic guidance in an in vivo porcine lung model.
Czech name
—
Czech description
—
Classification
Type
J<sub>ost</sub> - Miscellaneous article in a specialist periodical
CEP classification
—
OECD FORD branch
20601 - Medical engineering
Result continuities
Project
<a href="/en/project/EF16_019%2F0000765" target="_blank" >EF16_019/0000765: Research Center for Informatics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Respiratory Journal Open Research
ISSN
2312-0541
e-ISSN
2312-0541
Volume of the periodical
6
Issue of the periodical within the volume
10
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
—
UT code for WoS article
000603682700025
EID of the result in the Scopus database
—