Temperature-dependent dielectric properties of human uterine fibroids over microwave frequencies

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F21%3A00357379" target="_blank" >RIV/68407700:21230/21:00357379 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1088/2057-1976/ac27c2" target="_blank" >https://doi.org/10.1088/2057-1976/ac27c2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1088/2057-1976/ac27c2" target="_blank" >10.1088/2057-1976/ac27c2</a>

Result language

angličtina

Original language name

Temperature-dependent dielectric properties of human uterine fibroids over microwave frequencies

Original language description

Microwave ablation is under investigation as a minimally-invasive treatment for uterine fibroids. Computational models play a vital role in the development, evaluation and characterization of candidate ablation devices. The temperature-dependent dielectric properties of fibroid tissue are essential for accurate computational modeling. Objective: To measure the broadband temperaturedependent dielectric properties of uterine fibroids excised during hysterectomy procedures. Methods: The open-ended coaxial probe method was employed for measuring the broadband dielectric properties of freshly excised human uterine fibroid samples (n=6) obtained from an IRB-approved tissue bank. The dielectric properties (relative permittivity, εr, and effective electrical conductivity,σeff) were evaluated at temperatures ranging from 23 °C–150 °C, over the frequency range of 0.5–6 GHz. Linear piecewise parametrization with respect to temperature and quadratic parametrization with respect to frequency was applied to characterize broadband temperature-dependent dielectric properties of fibroid tissue. Results: The baseline room temperature values of εr vary from 57.5±5.29 to 44.5±5.77 units and σeff changes from 0.91±0.19 to 6.02±0.7 Sm-1 over the frequency range of 0.5–6 GHz. At temperatures close to the water vaporization point, εr, drops considerably i.e. to 12%–14% of its baseline value for all measured frequencies. σeff values initially rise till 98 °C and then fall to 11%–13% of their baseline values at 125 °C for frequencies„2.45 GHz. The σeff follows a decreasing trend for frequencies>2.45 GHz and drops to~6%of their baseline room temperature values. Conclusion: The temperature dependent dielectric properties of uterine fibroid tissues over microwave frequency range are reported for the first time in this study. Parametric models of uterine fibroid dielectric properties are also presented for incorporation within computational models of microwave ablation of fibroids.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

Project

<a href="/en/project/EF16_019%2F0000765" target="_blank" >EF16_019/0000765: Research Center for Informatics</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Physics & Engineering Express

ISSN

2057-1976

e-ISSN

2057-1976

Volume of the periodical

7

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

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UT code for WoS article

000711650900001

EID of the result in the Scopus database

2-s2.0-85119056948