Automated speech analysis in early untreated Parkinson's disease: Relation to gender and dopaminergic transporter imaging
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F22%3A00353213" target="_blank" >RIV/68407700:21230/22:00353213 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/22:10435002 RIV/00064165:_____/22:10435002
Result on the web
<a href="https://doi.org/10.1111/ene.15099" target="_blank" >https://doi.org/10.1111/ene.15099</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/ene.15099" target="_blank" >10.1111/ene.15099</a>
Alternative languages
Result language
angličtina
Original language name
Automated speech analysis in early untreated Parkinson's disease: Relation to gender and dopaminergic transporter imaging
Original language description
Background The mechanisms underlying speech abnormalities in Parkinson's disease (PD) remain poorly understood, with most of the available evidence based on male patients. This study aimed to estimate the occurrence and characteristics of speech disorder in early, drug-naive PD patients with relation to gender and dopamine transporter imaging. Methods Speech samples from 60 male and 40 female de novo PD patients as well as 60 male and 40 female age-matched healthy controls were analyzed. Quantitative acoustic vocal assessment of 10 distinct speech dimensions related to phonation, articulation, prosody, and speech timing was performed. All patients were evaluated using [123]I-2b-carbomethoxy-3b-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single-photon emission computed tomography and Montreal Cognitive Assessment. Results The prevalence of speech abnormalities in the de novo PD cohort was 56% for male and 65% for female patients, mainly manifested with monopitch, monoloudness, and articulatory decay. Automated speech analysis enabled discrimination between PD and controls with an area under the curve of 0.86 in men and 0.93 in women. No gender-specific speech dysfunction in de novo PD was found. Regardless of disease status, females generally showed better performance in voice quality, consonant articulation, and pauses production than males, who were better only in loudness variability. The extent of monopitch was correlated to nigro-putaminal dopaminergic loss in men (r = 0.39, p = 0.003) and the severity of imprecise consonants was related to cognitive deficits in women (r = -0.44, p = 0.005). Conclusions Speech abnormalities represent a frequent and early marker of motor abnormalities in PD. Despite some gender differences, our findings demonstrate that speech difficulties are associated with nigro-putaminal dopaminergic deficits.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
<a href="/en/project/NV19-04-00120" target="_blank" >NV19-04-00120: Objective investigation of distinct speech phenotypes in newly diagnosed Parkinson's disease including effects of pharmacotherapy</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Neurology
ISSN
1351-5101
e-ISSN
1468-1331
Volume of the periodical
29
Issue of the periodical within the volume
January
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
81-90
UT code for WoS article
000696723700001
EID of the result in the Scopus database
2-s2.0-85114999091