Dysprosody in Isolated REM Sleep Behavior Disorder with Impaired Olfaction but Intact Nigrostriatal Pathway
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F22%3A00357605" target="_blank" >RIV/68407700:21230/22:00357605 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/22:10442908 RIV/00216208:11110/22:10442908
Result on the web
<a href="https://doi.org/10.1002/mds.28873" target="_blank" >https://doi.org/10.1002/mds.28873</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/mds.28873" target="_blank" >10.1002/mds.28873</a>
Alternative languages
Result language
angličtina
Original language name
Dysprosody in Isolated REM Sleep Behavior Disorder with Impaired Olfaction but Intact Nigrostriatal Pathway
Original language description
Background Impairments of olfactory and speech function are likely early prodromal symptoms of alpha-synucleinopathy. Objective The aim of this study is to assess whether dysprosody is present in isolated rapid eye movement sleep behavior disorder (iRBD) with hyposmia/anosmia and a normal nigrostriatal system. Methods Pitch variability during speech was investigated in 17 iRBD subjects with normal olfactory function (iRBD-NOF), 30 iRBD subjects with abnormal olfactory function (iRBD-AOF), and 50 healthy controls. iRBD subjects were evaluated using the University of Pennsylvania Smell Identification Test and [123I]-2ss-carbomethoxy-3ss-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane dopamine transporter single-photon emission computed tomography (DAT-SPECT). All iRBD subjects completed the 24-month follow-up with DAT-SPECT, speech, and olfactory testing. Results At baseline, only iRBD-AOF showed monopitch when compared to iRBD-NOF (P = 0.04) and controls (P = 0.03), with no difference between iRBD-NOF and controls (P = 1). At follow-up, dysprosody progressed only in iRBD-AOF with abnormal DAT-SPECT (P = 0.03). Conclusion Prosody is impaired in hyposmic but not in normosmic iRBD subjects before the nigrostriatal dopaminergic transmission is affected (Braak stage 2). (c) 2021 International Parkinson and Movement Disorder Society
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
<a href="/en/project/NU20-08-00445" target="_blank" >NU20-08-00445: Smart Speech Biomarkers for Parkinson’s Disease and Other Synucleinopathies</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
MOVEMENT DISORDERS
ISSN
0885-3185
e-ISSN
1531-8257
Volume of the periodical
37
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
619-623
UT code for WoS article
000722827800001
EID of the result in the Scopus database
2-s2.0-85119977257