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Linguistic Abnormalities in Isolated Rapid Eye Movement Sleep Behavior Disorder

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F22%3A00360050" target="_blank" >RIV/68407700:21230/22:00360050 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/22:10447181 RIV/00064165:_____/22:10447181

  • Result on the web

    <a href="https://doi.org/10.1002/mds.29140" target="_blank" >https://doi.org/10.1002/mds.29140</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/mds.29140" target="_blank" >10.1002/mds.29140</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Linguistic Abnormalities in Isolated Rapid Eye Movement Sleep Behavior Disorder

  • Original language description

    Background: Patients with synucleinopathies frequently display language abnormalities. However, whether patients with isolated rapid eye movement sleep behavior disorder (iRBD) have prodromal language impairment remains unknown. Objectives: We examined whether the linguistic abnormalities in iRBD can serve as potential biomarkers for conversion to synucleinopathy, including the possible effect of mild cognitive impairment (MCI), speaking task, and automation of analysis procedure. Methods: We enrolled 139 Czech native participants, including 40 iRBD without MCI and 14 iRBD with MCI compared to 40 PD without MCI, 15 PD with MCI, and 30 healthy controls. Spontaneous discourse and story tale narrative were transcribed and linguistically annotated. A quantitative analysis was performed computing 3 linguistic features. Human annotations were compared to fully-automated annotations. Results: Compared to controls, iRBD patients showed poorer content density, reflecting the reduction of content words and modifiers. Both PD and iRBD subgroups with MCI manifested less occurrence of unique words and a higher number of n-grams repetitions, indicating poorer lexical richness. The spontaneous discourse task demonstrated language impairment in iRBD without MCI with an area under the curve of 0.72, while the story tale narrative task better reflected the presence of MCI, discriminating both PD and iRBD subgroups with MCI from controls with an area under the curve of up to 0.81. A strong correlation between manually and automatically computed results was achieved. Conclusions: Linguistic features might provide a reliable automated method for detecting cognitive decline due to prodromal neurodegeneration in subjects with iRBD, providing critical outcomes for future therapeutic trials.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30210 - Clinical neurology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    MOVEMENT DISORDERS

  • ISSN

    0885-3185

  • e-ISSN

    1531-8257

  • Volume of the periodical

    37

  • Issue of the periodical within the volume

    9

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    11

  • Pages from-to

    1872-1882

  • UT code for WoS article

    000825363800001

  • EID of the result in the Scopus database

    2-s2.0-85133541774