A coupled mechano-biochemical model for bone adaptation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F14%3A00211667" target="_blank" >RIV/68407700:21340/14:00211667 - isvavai.cz</a>
Alternative codes found
RIV/61388998:_____/14:00398880 RIV/49777513:23640/14:43924161
Result on the web
<a href="http://link.springer.com/article/10.1007%2Fs00285-013-0736-9" target="_blank" >http://link.springer.com/article/10.1007%2Fs00285-013-0736-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00285-013-0736-9" target="_blank" >10.1007/s00285-013-0736-9</a>
Alternative languages
Result language
angličtina
Original language name
A coupled mechano-biochemical model for bone adaptation
Original language description
Bone remodelling is a fundamental biological process that controls bone microrepair, adaptation to environmental loads and calcium regulation among other important processes. It is not surprising that bone remodelling has been subject of intensive both experimental and theoretical research. In particular, many mathematical models have been developed in the last decades focusing in particular aspects of this complicated phenomenon where mechanics, biochemistry and cell processes strongly interact. In this paper, we present a new model that combines most of these essential aspects in bone remodelling with especial focus on the effect of the mechanical environment into the biochemical control of bone adaptation mainly associated to the well known RANKL-RANK-OPG pathway. The predicted results show a good correspondence with experimental and clinical findings. For example, our results indicate that trabecular bone is more severely affected both in disuse and disease than cortical bone what
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BJ - Thermodynamics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED2.1.00%2F03.0088" target="_blank" >ED2.1.00/03.0088: Centre of the New Technologies and Materials</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Mathematical Biology
ISSN
0303-6812
e-ISSN
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Volume of the periodical
69
Issue of the periodical within the volume
6-7
Country of publishing house
DE - GERMANY
Number of pages
47
Pages from-to
1383-1429
UT code for WoS article
000344917300003
EID of the result in the Scopus database
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