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Effect of mobile phase salinity on the Ac-227/Ra-223 generator

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F14%3A00218489" target="_blank" >RIV/68407700:21340/14:00218489 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Effect of mobile phase salinity on the Ac-227/Ra-223 generator

  • Original language description

    Radium-223 is the first approved alpha emitting radionuclide for use in radionuclide therapy [1]. Radium follows the Calcium metabolism and thus is self targeted to bones. Several generator systems were described in the past [2]. In this study we have focused on a generator system described by Guseva et al. [3], based on a Dowex-1 resin and a mixed methanol/ nitric acid mobile phase. The effect of NaCl addition into a mobile phase on Ac-227/Th-227/Ra-223 generator was studied. The aim of this study wasto increase the efficiency of Ra-223 elution and improvement of the Ra-223 elution peak shape. Possible Th-227 breakthrough was also evaluated. Acknowledgement: This work was supported by the Ministry of Education Youth and Sports of the Czech republic,grant No.: LK21310.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

    CH - Nuclear and quantum chemistry, photo chemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/LK21310" target="_blank" >LK21310: Study of transmutation of Ra-226 and its separation from activation products</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů