Production of the positron-emitting radionuclide 68Ga: the radiochemical scheme of radionuclide generator 68Ge -> 68Ga

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F18%3A00322981" target="_blank" >RIV/68407700:21340/18:00322981 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.15328/cb1003" target="_blank" >http://dx.doi.org/10.15328/cb1003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.15328/cb1003" target="_blank" >10.15328/cb1003</a>

Result language

ruština

Original language name

Получение позитрон-излучающего радионуклида 68Ga: радиохимическая схема радионуклидного генератора 68Ge -> 68Ga

Original language description

68Ga (T1 / 2 = 68 min) in complexes with peptides is used in positron emission tomography for diagnostics of neuroendocrine tumors. The most promising strategy for 68Ga production is usage of the radionuclide generator 68Ge -> 68Ga. In this research, the sorption behavior of Ge(IV) and Ga (III) has been studied. The distribution coefficients (Kd) of Ge(IV) on the anion exchange (Dowex 1x8) and cation exchange (Dowex 50x8) resins in various ethanedioic and hydrochloric acid solutions were determined. For each ion exchange resin, four series of measurements were carried out, in which the concentration of oxalic acid was fixed (0.001 M, 0.003 M, 0.005 M, 0.01 M), and the concentrations of hydrochloric acid ranged from 0 to 3 M. Based on the distribution coefficients, the chemical scheme of the radionuclide generator 68Ge -> 68Ga has been developed. The chemical system is based on the anion exchange resin Dowex 1x8 and mixture of 0.005 M C2H2O4 / 0.33 M HCl. Several types of the generators with direct and reverse mode of elution were tested and the optimal scheme was determined. Elution of the generators was performed once a day with 8 ml of 0.005 M C2H2O4 / 0.33 M HCl solution. The 68Ga yield and the 68Ge breakthrough are comparable for all the systems.

Czech name

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Czech description

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Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

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OECD FORD branch

10402 - Inorganic and nuclear chemistry

Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemical Bulletin of Kazakh National University

ISSN

1563-0331

e-ISSN

2312-7554

Volume of the periodical

2018

Issue of the periodical within the volume

2

Country of publishing house

KZ - KAZAKSTAN

Number of pages

7

Pages from-to

20-26

UT code for WoS article

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EID of the result in the Scopus database

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