GALIUM-68 LABELLING ON THE MICROFLUIDIC SYSTEMS

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F18%3A00323793" target="_blank" >RIV/68407700:21340/18:00323793 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
GALIUM-68 LABELLING ON THE MICROFLUIDIC SYSTEMS
Original language description
The use of the microfluidic systems in the production of the radiopharmaceuticals is a new direction to obtain a product of high purity and high specific activity. Increasing employing of gallium-68 radiopharmaceuticals in nuclear medicine for tumor imaging by positron emission tomography require to find a new and efficient synthetic strategies. Radiolabelling procedure was performed on a system consisting of high-pressure HPLC pumps, connected with two manual Rheodyne valves, joined to microfluidic chip plugged in heating device with temperature sensor. Microfluidic chips were made from PMMA matrix with the column (approx. 10x4 mm) containing C18 sorbent. In the homogeneous labelling, precursor was mixed in the reactor with generator eluate containing gallium-68 (30 MBq) and then was trapped on the sorbent. In the heterogeneous labelling, precursor was trapped on the sorbent and then was labelled with eluate containing gallium-68 (58 MBq). Analysis was carried out LC/MS system. The yield of gallium-68 labelled precursor of DOTA-Substance P was 41 %
Czech name
—
Czech description
—

Project
<a href="/en/project/TJ01000334" target="_blank" >TJ01000334: Novel composite materials for medical radionuclides separation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)