Development of Ge-68/Ga-68 radionuclide generator for nuclear medicine

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F19%3A00334660" target="_blank" >RIV/68407700:21340/19:00334660 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Development of Ge-68/Ga-68 radionuclide generator for nuclear medicine

Original language description

This work was focused on the development of Ge-68/Ga-68 generator system based on the nanocomposites of cerium(IV) and zirconium(IV) in the polyacrylonitrile matrix. These perspective stationary phases should provide eluate in excellent quality. Cerium(IV), zirconium(IV) and titanium(IV) oxides and hydroxides were studied as potential active ion-exchanger components. All materials were characterized by X-ray powder diffraction, transmission and scanning electron microscopy, FT-IR and Raman spectrometry. Sorption properties of these materials were examined by the measurement of equilibrium distribution coefficients, Dw, of Ge-68 and Ga-68 in the presence of diluted hydrochloric acid (concentrations: 1 mol/l; 0.1 mol/l; 0.01 mol/l and 0.001 mol/l). On the basis of the separation factor, α, the optimal concentration of hydrochloric acid was determined and two materials with the best separation factor, cerium(IV) oxide and zirconium(IV) hydroxide, were granulated into the polyacrylonitrile matrix. Prepared composites were used for the construction of two model generators with bed volume of 0.57 ml and 1.6 MBq of Ge-68 and 1 MBq of Ge-68 for cerium(IV) oxide and for zirconium(IV) hydroxide, respectively. Elution curves, yields of elution and contamination percentages were determined for both prepared model generators. The optimal medium for separating these radionuclides is 0.1mol/l hydrochloric acid (α = 26 857 for cerium(IV) oxide and α = 4 949 for zirconium(IV) hydroxide). Experiments with model generators gave us some very promising results and in the upcoming study the separation qualities and radiation stability of cerium(IV) oxide composite has to be confirmed using higher activities of Ge-68.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

10402 - Inorganic and nuclear chemistry

Project

<a href="/en/project/TJ01000334" target="_blank" >TJ01000334: Novel composite materials for medical radionuclides separation</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů