The developmental basis of fingerprint pattern formation and variation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F23%3A00367599" target="_blank" >RIV/68407700:21340/23:00367599 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.cell.2023.01.015" target="_blank" >https://doi.org/10.1016/j.cell.2023.01.015</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cell.2023.01.015" target="_blank" >10.1016/j.cell.2023.01.015</a>
Alternative languages
Result language
angličtina
Original language name
The developmental basis of fingerprint pattern formation and variation
Original language description
Fingerprints are complex and individually unique patterns in the skin. Established prenatally, the molecular and cellular mechanisms that guide fingerprint ridge formation and their intricate arrangements are unknown. Here we show that fingerprint ridges are epithelial structures that undergo a truncated hair follicle develop-mental program and fail to recruit a mesenchymal condensate. Their spatial pattern is established by a Turing reaction-diffusion system, based on signaling between EDAR, WNT, and antagonistic BMP pathways. These signals resolve epithelial growth into bands of focalized proliferation under a precociously differentiated suprabasal layer. Ridge formation occurs as a set of waves spreading from variable initiation sites defined by the local signaling environments and anatomical intricacies of the digit, with the propagation and meeting of these waves determining the type of pattern that forms. Relying on a dynamic patterning system triggered at spatially distinct sites generates the characteristic types and unending variation of human fingerprint patterns.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
<a href="/en/project/EF16_019%2F0000778" target="_blank" >EF16_019/0000778: Center for advanced applied science</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cell
ISSN
0092-8674
e-ISSN
1097-4172
Volume of the periodical
186
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
17
Pages from-to
940-956
UT code for WoS article
000953138500001
EID of the result in the Scopus database
2-s2.0-85149060950