Terbium-161 production and quality control
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F24%3A00378184" target="_blank" >RIV/68407700:21340/24:00378184 - isvavai.cz</a>
Result on the web
<a href="https://events.ncbj.gov.pl/event/322/attachments/601/976/Book_of_abstracts.pdf" target="_blank" >https://events.ncbj.gov.pl/event/322/attachments/601/976/Book_of_abstracts.pdf</a>
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Terbium-161 production and quality control
Original language description
Terbium-161 is a promising radionuclide for medicinal use. Its physical characteristics make it a great candidate for theranostic use. It decays with half-life of 6,89 days while emitting beta minus particles with maximum energy 593 keV and avarege energy 154 keV. Tb-161 also emits 12,4 conversion and Auger electrons per decay which enhances its therapeutic efficiency. In addition, gamma radiation with energy 74 keV is emitted, which can be used for SPECT imaging1. No carrier added terbium-161 can be prepared by irradiating Gd in form of oxide or nitrate highly enriched with 160Gd in nuclear reactor. Terbium-161 was produced by irradiation of highly enriched gadolinium-160 (98,6 %) in the oxide form in the nuclear reactor LVR 15 (CV Řež). Terbium-161 was separated by cation exchange chromatography with the resin Dowex 50Wx8 with alpha-hydroxyisobutyric acid (αHIBA) as eluent. Collected fraction were repurified from α-HIBA on a smaller column using the same cation exchange resin. The purity of prepared Tb-161 was verified by gamma spectrometry on an HPGe detector and by ICP-MS. Quality control of Tb-161 solution was evaluated by radiolabelling DOTA molecule in various molar ratios of Tb: DOTA in various time periods after the end of separation. One batch typically yields 3,9 – 22 GBq of no carried added 161-Tb with radionuclide purity higher than 99,999 %, which is sufficient as 1 – 3 therapeutical doses.
Czech name
—
Czech description
—
Classification
Type
O - Miscellaneous
CEP classification
—
OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
<a href="/en/project/TO01000074" target="_blank" >TO01000074: Efficient Low-energy Electron Cancer Therapy with Terbium-161</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů