Interaction of Recombinant Interleukins IL-4 and IL-4A2 with IL-4R I and IL-4R 11 Receptors In Silico

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F10%3A00168999" target="_blank" >RIV/68407700:21460/10:00168999 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Interaction of Recombinant Interleukins IL-4 and IL-4A2 with IL-4R I and IL-4R 11 Receptors In Silico

Original language description

Alternative splicing is actively involved in shaping of cytokine regulation polymorphism, and splice isoforms of protein cytokines and their receptors can significantly alter the regulatory functions of various cytokines. IL-482 is a naturally occurringsplice variant of human IL-4. In IL-482, the second exon ofIL-4 is omitted by alternative splicing, with exons 1,3, and 4 joined in an open reading frame. Unlike IL-4, IL-482 do not act as a costimulator for T cell proliferation. However, IL-482 inhibitsthe ability of complete IL-4 to act as a T cell costimulator. Study of IL-482 interactions with its receptors IL-4R I and IL-4R II can help in creating of new pharmaceuticals for the treatment of bronchial asthma, various leukemias, melanoma, breast cancer.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

FS - Medical facilities, apparatus and equipment

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Workshop 2010

ISBN

978-80-01-04513-8

ISSN

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e-ISSN

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Number of pages

2

Pages from-to

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Publisher name

České vysoké učení technické v Praze

Place of publication

Praha

Event location

Praha

Event date

Feb 22, 2010

Type of event by nationality

EUR - Evropská akce

UT code for WoS article

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