Optical Detection of Charged Biomolecules: Towards Novel Drug Delivery Systems
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F11%3A00183547" target="_blank" >RIV/68407700:21460/11:00183547 - isvavai.cz</a>
Result on the web
<a href="http://ctn.cvut.cz/ap/index.php?year=2011&idissue=75" target="_blank" >http://ctn.cvut.cz/ap/index.php?year=2011&idissue=75</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Optical Detection of Charged Biomolecules: Towards Novel Drug Delivery Systems
Original language description
This paper presents work done on developing optically-traceable intracellular nanodiamond sensors, where the photoluminescence can be changed by a biomolecular attachment/delivery event. Their high biocompatibility, small size and stable luminescence from their color centers make nanodiamond (ND) particles an attractive alternative to molecular dyes for drug-delivery and cell-imaging applications. In our work, we study how surface modification of ND can change the color of ND luminescence (PL). This method can be used as a novel detection tool for remote monitoring of chemical processes in biological systems. Recently, we showed that PL can be driven by atomic functionalization, leading to a change in the color of ND luminescence from red (oxidized ND)to orange (hydrogenated ND). In this work, we show how PL of ND changes similarly when interacting with positively and negatively charged molecules. The effect is demonstrated on fluorinated ND,
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LD11078" target="_blank" >LD11078: Real time nanophotonic imaging in cells using nanodiamond particles</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta Polytechnica
ISSN
1210-2709
e-ISSN
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Volume of the periodical
2011
Issue of the periodical within the volume
5
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
5
Pages from-to
89-93
UT code for WoS article
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EID of the result in the Scopus database
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