The assessment of electrophysiological indices and ECG parameters as predictors of fatal arrhythmias under ischemia/reperfusion setting in multivariate regression model

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F18%3A00327568" target="_blank" >RIV/68407700:21460/18:00327568 - isvavai.cz</a>

Result on the web

<a href="https://www.fasebj.org/doi/10.1096/fasebj.2018.32.1_supplement.lb315" target="_blank" >https://www.fasebj.org/doi/10.1096/fasebj.2018.32.1_supplement.lb315</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The assessment of electrophysiological indices and ECG parameters as predictors of fatal arrhythmias under ischemia/reperfusion setting in multivariate regression model

Original language description

The aim of the study was to find out which of the electrophysiological indices and ECG parameters contribute significantly to the genesis of fatal arrhythmias under experimental coronary occlusion and reperfusion using multivariate regression model. Methods. Using needle plunge electrodes unipolar electrograms were recorded in intramural ventricular layers of 24 anesthetized open-chest cats. Activation times (ATs) as dV/dt min during QRS, end of repolarization times (RTs) as dV/dt max during ST-T, and activation-recovery intervals (ARIs) as the time interval between the ATs and RTs were measured in total of 88 myocardial leads. The global, apicobasal, border RT dispersions were calculated as electrophysiological indices. The data were obtained at baseline, at 1 and 30 min of coronary occlusion and at 1 and 30 min of reperfusion. Results. The ventricular tachycardia and/or ventricular fibrillation (VT/VF) arose in a total of 10 animals at 1–5 minutes after reperfusion onset. Using the multivariate logistic regression analysis we assessed the association between the dispersions of RT, RTs and ATs of ischemic and nonischemic zone under the 1 min of reperfusion and the occurrence of VT/VF. It was found that RTs of nonischemic zone (P=0.024) and global dispersion of RT (P=0.046) demonstrated significant association with the reperfusion VT/VF. The following ECG parameters as predictors of arrhythmias were tested (heart rate, Tpeak-Tend, QRS and QTc intervals, Tpeak-Tend/QT ratio). The QRS interval (P=0.01) and heart rate (P=0.009) were found to have the significant link with the occurrence of VT/VF. Conclusion. The multivariate regression model showed that the genesis of VT/VF was independently predicted by the repolarization duration in nonischemic area and the global dispersion of repolarization at the reperfusion onset. The QRS and heart rate were the independent ECG predictors of the occurrence of reperfusion VT/VF.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

30109 - Pathology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů