The Accuracy of Noninvasive Localization of Ectopic Focus: Simulation Study of the Impact of Focus Position and Used ECG Leads

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F18%3A00329831" target="_blank" >RIV/68407700:21460/18:00329831 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.jelectrocard.2018.10.010" target="_blank" >http://dx.doi.org/10.1016/j.jelectrocard.2018.10.010</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jelectrocard.2018.10.010" target="_blank" >10.1016/j.jelectrocard.2018.10.010</a>

Result language

angličtina

Original language name

The Accuracy of Noninvasive Localization of Ectopic Focus: Simulation Study of the Impact of Focus Position and Used ECG Leads

Original language description

Introduction: Noninvasive preoperative localization of the premature ventricular contraction (PVC) focus can significantly decrease the time of the electrophysiological study and improve the radiofrequency ablation outcome. The impact of the focus position and configuration of measured ECG leads on the focus localization error was studied. Methods: ECGSim software was used to simulate PVCs starting in both ventricles with ectopic foci located in anterior, lateral, posterior, and septal segments. In each segment, fifteen foci were simulated: 5 epicardial, 5 endocardial and 5 placed near the valve. For each simulation, cardiac electric generator represented by an equivalent double layer was used to solve the forward problem of electrocardiography and to calculate body surface potentials (BSPs) in three lead configurations: 64 Nijmegen leads, 192 leads in 16x12 grid, and 300 leads in the torso model nodes. Each focus was then localized by solving the inverse problem with a single dipole as the equivalent cardiac generator. Integral BSPs from the initial 5 ms of the premature activation and inhomogeneous torso model including body surface, lungs, and ventricular cavities were used in the computations. The localization error (LE) was defined as the distance between the location of the simulated focus and the location found by the inverse solution. Results: The LE varied from 0.36 to 33.52 mm. For 192 and 300 leads the LEs were similar, with slightly higher values for foci in the left ventricle. For 64 leads, the LEs were much larger, with significantly higher values for foci in the right ventricle (p<0.05). Conclusions: The LE was dependent on both, position of the ectopic focus and the used ECG leads. Increased number of leads above 192 did not improve the accuracy of the inverse localization. The use of 64 non-uniformly distributed leads resulted in higher LEs and increased impact of the focus position.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů