EEG Correlates of the Effect of Psychedelics in Rat – Spectral Maps and Coherence

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F18%3A00331240" target="_blank" >RIV/68407700:21460/18:00331240 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

EEG Correlates of the Effect of Psychedelics in Rat – Spectral Maps and Coherence

Original language description

All known psychedelics are 5-HT2A receptor agonists and induce extensive psychological changes. Abnormal function of serotonergic transmission is seen today as one of the etiopathogenetic factors of schizophrenia. Therefore, psychedelics are used to model this disease. The representatives of two main classes – tryptamines and phenethylamines were used in our study. We measured cortical EEG under 12 electrodes in freely moving intoxicated rats. Electrodes were stereotactically implanted on the surface of rat’s brain and fixed to the skull. EEG was recorded 7 days post-surgery. After a baseline EEG record (10 minutes), the treatment was administered and registration continued for another 90 minutes. Along with EEG, behavioral activity was co-registered. Only data corresponding to inactivity was used for further analysis. Data was performed in Neuroguide and BrainVision softwares and in-house built Matlab toolbox. Spectral analysis results were mapped on the surface of a rat brain via 3D spline mapping method, change of coherence was plotted on a real rat brain image. All treatments primarily resulted in significant decrease of spectral power (with some increase-exceptions) and EEG coherence. Both tryptamines induced spectral power decrease in beta-band frequencies (psilocin more in temporal, LSD in parietal areas) and mainly in high gamma range (over 40 Hz). Few changes were seen after mescaline, whereas DOB caused strong decrease across beta frequency band in upper cortex areas. Coherence decrease of delta and theta frequencies globally and of higher frequencies in fronto-temporal inter-hemispherical connections was characteristic for all treatments. Serotonergic hallucinogens induce typical electrophysiological changes during behavioral inactivity in the rat brain characterized generally by decrease in absolute spectral power, local desynchronization and disconnection of long projections.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů