Computer model of oxygenation in neonates: A demonstration of utility
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F19%3A00333882" target="_blank" >RIV/68407700:21460/19:00333882 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1515/cdbme-2019-0019" target="_blank" >https://doi.org/10.1515/cdbme-2019-0019</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/cdbme-2019-0019" target="_blank" >10.1515/cdbme-2019-0019</a>
Alternative languages
Result language
angličtina
Original language name
Computer model of oxygenation in neonates: A demonstration of utility
Original language description
Maintaining a prescribed peripheral oxygen saturation (SpO2) target during routine care of neonates is challenging and inspired fraction of oxygen (FiO2) titration practices differ among caregivers and centers. Algorithms for automatic feedback control of SpO2 are being developed and tested, that would adapt to the changing neonatal organism and better maintain the required SpO2 target range. While clinical data is necessary to validate differences in the titration strategies, a continuous physiological model of oxygenation in neonates would facilitate baseline testing of different approaches, manual or automated. The objective of our study was to enhance a mathematical model of oxygenation of the neonate and to compare the performance of the model with available clinical data. We have implemented the diffusion resistance into the model as well as a variable oxyhemoglobin dissociation relationship and the bias between arterial and peripheral oxygen saturation. Values of model parameters were scaled to fit preterm infant scenarios. The comparison of the clinical data and computer simulations suggest that the model can reliably simulate episodes of oxygen desaturation and describe the relation between ventilation, FiO2 and SpO2. It appears that the model may be an effective tool to test manual and automatic FiO2 titration strategies.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
20601 - Medical engineering
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Directions in Biomedical Engineering
ISSN
2364-5504
e-ISSN
2364-5504
Volume of the periodical
5
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
4
Pages from-to
73-76
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-85072642292