Neuroprotection in glaucoma-electrophysiology

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F20%3A00347858" target="_blank" >RIV/68407700:21460/20:00347858 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.3892/etm.2020.8509" target="_blank" >https://doi.org/10.3892/etm.2020.8509</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3892/etm.2020.8509" target="_blank" >10.3892/etm.2020.8509</a>

Result language
angličtina
Original language name
Neuroprotection in glaucoma-electrophysiology
Original language description
Hypertensive glaucoma is defined as a group of diseases with progressive loss of the neuroretinal margin of the optic disc that causes characteristic degenerative optic neuropathy. The present study provided an updated summary of the physiology and pathology of neurotransmission in the visual path, with the focus on glaucoma. The results of positron emission tomography, functional magnetic resonance imaging and mainly electrophysiological methods demonstrated pathogenesis of nerve cell damage in the visual pathway. Based on these conclusions, neuroprotection in glaucoma was proposed. This consists mainly of the reduction of the intraocular pressure. It is followed by a decrease of glutamate in the synaptic cleft and blockade of its binding to the NMDA receptors. The supply of energy substrates to altered nerve cells is also indispensable. Therapy should be systemic due to impairment of the complete visual path.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30207 - Ophthalmology

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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