The invisible costs of obstructive sleep apnea (OSA): Systematic review and cost-of-illness analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F22%3A00346974" target="_blank" >RIV/68407700:21460/22:00346974 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1371/journal.pone.0268677" target="_blank" >https://doi.org/10.1371/journal.pone.0268677</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0268677" target="_blank" >10.1371/journal.pone.0268677</a>
Alternative languages
Result language
angličtina
Original language name
The invisible costs of obstructive sleep apnea (OSA): Systematic review and cost-of-illness analysis
Original language description
Background Obstructive sleep apnea (OSA) is a risk factor for several diseases and is correlated with other non-medical consequences that increase the disease’s clinical and economic burden. However, OSA’s impact is highly underestimated, also due to substantial diagnosis gaps. Objective This study aims at assessing the economic burden of OSA in the adult population in Italy by performing a cost-of-illness analysis with a societal perspective. In particular, we aimed at estimating the magnitude of the burden caused by conditions for which OSA is a proven risk factor. Methods A systematic literature review on systematic reviews and meta-analyses, integrated by expert opinion, was performed to identify all clinical and non-clinical conditions significantly influenced by OSA. Using the Population Attributable Fraction methodology, a portion of their prevalence and costs was attributed to OSA. The total economic burden of OSA for the society was estimated by summing the costs of each condition influenced by the disease, the costs due to OSA’s diagnosis and treatment and the economic value of quality of life lost due to OSA’s undertreatment. Results Twenty-six clinical (e.g., diabetes) and non-clinical (e.g., car accidents) conditions were found to be significantly influenced by OSA, contributing to an economic burden ranging from 10.7 to 32.0 billion/year in Italy. The cost of impaired quality of life due to OSA undertreatment is between 2.8 and 9.0 billion/year. These costs are substantially higher than those currently borne to diagnose and treat OSA (234 million/year). Conclusions This study demonstrates that the economic burden due to OSA is substantial, also due to low diagnosis and treatment rates. Providing reliable estimates of the economic impact of OSA at a societal level may increase awareness of the disease burden and help to guide evidence-based policies and prioritisation for healthcare, ultimately ensuring appropriate diagnostic and therapeutic pathways for patients.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30500 - Other medical sciences
Result continuities
Project
<a href="/en/project/EF16_027%2F0008465" target="_blank" >EF16_027/0008465: International Mobility of Researchers in CTU</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS ONE
ISSN
1932-6203
e-ISSN
1932-6203
Volume of the periodical
17
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
23
Pages from-to
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UT code for WoS article
001044846900027
EID of the result in the Scopus database
2-s2.0-85130501221