Discrete event simulation model for cost-effectiveness evaluation of screening for asymptomatic patients with lower extremity arterial disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F22%3A00358558" target="_blank" >RIV/68407700:21460/22:00358558 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.3390/ijerph191811792" target="_blank" >https://doi.org/10.3390/ijerph191811792</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijerph191811792" target="_blank" >10.3390/ijerph191811792</a>

Result language

angličtina

Original language name

Discrete event simulation model for cost-effectiveness evaluation of screening for asymptomatic patients with lower extremity arterial disease

Original language description

Lower limb ischemic disease (LEAD) affects a significant portion of the population, with most patients being asympto-matic. Patient screening is necessary because LEAD patients have an increased risk of occurrence other cardiovascular events and manifestations of disease in terms of leg symptoms such as intermittent claudication, critical limb ischemia or amputation. The aim of this work is to evaluate cost-effectiveness of screening using ABI diagnostics in asymptomatic patients and its impact on limb symptoms associated with LEAD. Discrete event simulation model was created for capturing lifetime costs and effects. Costs were calculated from the perspective of the health care payer and the effects were calculated as QALYs. The cost-effectiveness analysis was calculated to compare the ABI screening examination and the situation without such screening. The probabilistic sensitivity analysis and scenario analysis were calculated to evaluate the robustness of the results. In the basic setting, the screening intervention was a more expensive intervention at a cost of CZK 174,010, compared to CZK 70,177 for the strategy without screening. The benefits of screening were es-timated at 14.73 QALYs, and 14.46 QALYs without screening. The final ICER value of CZK 389,738 per QALY is below the willingness to pay threshold. The results of the simulated cost-effectiveness analysis suggest that screening using the ABI method is a cost-effective strategy. Likewise, the results of the probabilistic sensitivity analysis and of the scenario analysis are below the threshold of willingness to pay, thus confirming the robustness of the results.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

50602 - Public administration

Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Environmental Research and Public Health

ISSN

1661-7827

e-ISSN

1660-4601

Volume of the periodical

19

Issue of the periodical within the volume

18

Country of publishing house

CH - SWITZERLAND

Number of pages

16

Pages from-to

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UT code for WoS article

000858252500001

EID of the result in the Scopus database

2-s2.0-85138688463