Randomised control trial of oxygen assist module in preterm infants on high-flow nasal cannula support
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F24%3A00368805" target="_blank" >RIV/68407700:21460/24:00368805 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1136/archdischild-2023-325661" target="_blank" >https://doi.org/10.1136/archdischild-2023-325661</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1136/archdischild-2023-325661" target="_blank" >10.1136/archdischild-2023-325661</a>
Alternative languages
Result language
angličtina
Original language name
Randomised control trial of oxygen assist module in preterm infants on high-flow nasal cannula support
Original language description
Objective: To evaluate the efficacy of automatic oxygen control (A-FiO(2)) in reducing the extremes of oxygen saturations (SpO(2)98%) in preterm infants on high-flow nasal cannula (HFNC) respiratory support using Vapotherm Precision Flow.Design: A parallel-arm randomised controlled trial.Setting: A level-III neonatal intensive care unit.Patients: Preterm infants born <33 (23+0 to 32+6) weeks receiving HFNC as respiratory support.Interventions: A-FiO(2) versus manual (M-FiO(2)) oxygen control during the full course of HFNC support.Outcomes:The primary outcome of this study is percentage of time spent in extreme oxygen saturations (98%) in preterm infants when receiving HFNC as respiratory support. Secondary outcomes were time with SpO(2) between 90% and 95% plus time >95% without supplemental oxygen.Results: 60 infants were randomised equally to either A-FiO(2) or M-FiO(2) arm. Their baseline characteristics were comparable. They spent a median of 5.3 (IQR: 2.0-8.4) and 6.5 (IQR: 2.9-13.7) days in the study, A-FiO(2) and M-FiO(2), respectively. The percentage of time spent in SpO(2)<80% (median of 0.4% (0.1%-0.8%) vs 1.6% (0.6%-2.6%), p=0.002) and >98% (median 0.2% (0.1%-0.9%) vs 1.9% (0.7%-4%), p<0.001) were significantly lower in A-FiO(2) compared with M-FiO(2). The difference in median percentage of time in target range between the two arms was 26% (81% (74%-93%) in A-FiO(2) vs 55% (48%-72%) in M-FiO(2)).Conclusion: A-FiO(2) was associated with statistically significant reduction in the percentage of time spent in extremes of saturation when compared with M-FiO(2) in preterm infants receiving HFNC.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20601 - Medical engineering
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Archives of disease in childhood. Fetal and neonatal edition
ISSN
1359-2998
e-ISSN
1468-2052
Volume of the periodical
109
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
65-69
UT code for WoS article
001033880600001
EID of the result in the Scopus database
2-s2.0-85166434849