Proton Pencil Beam Scanning Radiotherapy in the Postoperative Treatment of P16 Positive Squamous Cell Tonsillar Cancer - Evaluation of Toxicity and Effectivity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F24%3A00382283" target="_blank" >RIV/68407700:21460/24:00382283 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1007/s00405-024-08747-1" target="_blank" >https://doi.org/10.1007/s00405-024-08747-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00405-024-08747-1" target="_blank" >10.1007/s00405-024-08747-1</a>

Result language

angličtina

Original language name

Proton Pencil Beam Scanning Radiotherapy in the Postoperative Treatment of P16 Positive Squamous Cell Tonsillar Cancer - Evaluation of Toxicity and Effectivity

Original language description

Purpose Patients with p16 positive tonsillar cancer (p16 + TC) have an excellent prognosis and long-life expectancy. Deintensification of therapy is a prevalent topic of discussion. Proton radiotherapy is one way to reduce radiation exposure and thus reduce acute and late toxicity. The aim is to evaluate treatment outcomes and toxicity of postoperative treatment with intensity-modulated proton therapy (IMPT).MethodsBetween September 2013 and November 2021, 47 patients with p16 + TC were treated postoperatively with IMPT. Median age was 54.9 (38.2-74.9) years, 31 were males and 16 were females. All patients had squamous cell carcinoma and underwent surgery as a primary treatment. Median dose of radiotherapy was 66 GyE in 33 fractions. Bilateral neck irradiation was used in 39 patients and unilateral in 8. Concomitant chemotherapy was applied in 24 patients.ResultsMedian follow-up time was 4.2 (0.15-9.64) years. Five-year overall survival, relapse free survival and local control were 95.7%, 97.8% and 100%. The most common acute toxicities were dermatitis and mucositis, with grade 2 + in 61.7% and 70.2% of patients. No acute percutaneous gastrostomy insertion was necessary and intravenous rehydration was used in 12.8% of patients. The most common late toxicity was grade 1 xerostomia in 70.2% of patients and grade 2 in 10.6% of patients. Subcutaneous fibrosis of grades 2 and 3 occurred in 17.0% and 2.1% of patients, respectively. One patient developed late severe dysphagia and became PEG-dependent.ConclusionIMPT for the postoperative treatment of p16 + TC is feasible with excellent efficiency and acceptable acute and late toxicity.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30224 - Radiology, nuclear medicine and medical imaging

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Archives of Oto Rhino Laryngology and Head & Neck

ISSN

0937-4477

e-ISSN

1434-4726

Volume of the periodical

281

Issue of the periodical within the volume

10

Country of publishing house

DE - GERMANY

Number of pages

8

Pages from-to

5447-5454

UT code for WoS article

001303688100003

EID of the result in the Scopus database

2-s2.0-85202541187