Dual MRI-SPECT imaging system realized with Timepix pixel detector inserted into MR small animal scanner

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21670%2F20%3A00344099" target="_blank" >RIV/68407700:21670/20:00344099 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1088/1742-6596/1662/1/012036" target="_blank" >https://doi.org/10.1088/1742-6596/1662/1/012036</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1088/1742-6596/1662/1/012036" target="_blank" >10.1088/1742-6596/1662/1/012036</a>

Result language

angličtina

Original language name

Dual MRI-SPECT imaging system realized with Timepix pixel detector inserted into MR small animal scanner

Original language description

Although MRI and SPECT are routine tools in medical imaging individually, the combination of these two modalities in multimodal imaging is still unexplored. By hybridizing high-resolution anatomical with functional imaging, combined MRI-SPECT could be a valuable addition to existing medical imaging methods, reducing overall scanning time and image coregistration errors. In contrast to PET, SPECT offers a cost-efficient range of applicable radioisotopes. This proof-of-principle study shows a modified experimental MRI-SPECT insert system consisting of an MR-compatible SPECT unit with hybrid semiconductor detectors Timepix. The insert system is equipped with CdTe pixelated sensors, tungsten collimators and a radiofrequency coil (RF). To increase the number of projections acquired, the setup is also equipped with an electromagnetic step motor Microcon SX 16-0503 for a sample rotation. Measurements were performed our own invented multimodal (1H/99mTc) inhomogeneous phantom filled with a liquid 99mTc radiotracer, emitting 140.5 keV γ-rays inside the RF coil by the Bruker BioSpec 47/20 (4.7 T) MR animal scanner. For the evaluation of measured data, SPECT-back projection software was developed in Matlab. Our results pave the way for a preclinical MRI-SPECT insert system. This research was performed in the framework of the Medipix Collaboration

Czech name

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Czech description

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Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

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OECD FORD branch

30500 - Other medical sciences

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Physics

ISSN

0143-0807

e-ISSN

1361-6404

Volume of the periodical

1662

Issue of the periodical within the volume

012036

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

2-7

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-85096364592