All
All

What are you looking for?

All
Projects
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Dual MRI-SPECT imaging system realized with Timepix pixel detector inserted into MR small animal scanner

Result description

Although MRI and SPECT are routine tools in medical imaging individually, the combination of these two modalities in multimodal imaging is still unexplored. By hybridizing high-resolution anatomical with functional imaging, combined MRI-SPECT could be a valuable addition to existing medical imaging methods, reducing overall scanning time and image coregistration errors. In contrast to PET, SPECT offers a cost-efficient range of applicable radioisotopes. This proof-of-principle study shows a modified experimental MRI-SPECT insert system consisting of an MR-compatible SPECT unit with hybrid semiconductor detectors Timepix. The insert system is equipped with CdTe pixelated sensors, tungsten collimators and a radiofrequency coil (RF). To increase the number of projections acquired, the setup is also equipped with an electromagnetic step motor Microcon SX 16-0503 for a sample rotation. Measurements were performed our own invented multimodal (1H/99mTc) inhomogeneous phantom filled with a liquid 99mTc radiotracer, emitting 140.5 keV γ-rays inside the RF coil by the Bruker BioSpec 47/20 (4.7 T) MR animal scanner. For the evaluation of measured data, SPECT-back projection software was developed in Matlab. Our results pave the way for a preclinical MRI-SPECT insert system. This research was performed in the framework of the Medipix Collaboration

Keywords

Gamma cameraMRI-SPECTMulti-modality systemsPixelated sensors

The result's identifiers

Alternative languages

  • Result language

    angličtina

  • Original language name

    Dual MRI-SPECT imaging system realized with Timepix pixel detector inserted into MR small animal scanner

  • Original language description

    Although MRI and SPECT are routine tools in medical imaging individually, the combination of these two modalities in multimodal imaging is still unexplored. By hybridizing high-resolution anatomical with functional imaging, combined MRI-SPECT could be a valuable addition to existing medical imaging methods, reducing overall scanning time and image coregistration errors. In contrast to PET, SPECT offers a cost-efficient range of applicable radioisotopes. This proof-of-principle study shows a modified experimental MRI-SPECT insert system consisting of an MR-compatible SPECT unit with hybrid semiconductor detectors Timepix. The insert system is equipped with CdTe pixelated sensors, tungsten collimators and a radiofrequency coil (RF). To increase the number of projections acquired, the setup is also equipped with an electromagnetic step motor Microcon SX 16-0503 for a sample rotation. Measurements were performed our own invented multimodal (1H/99mTc) inhomogeneous phantom filled with a liquid 99mTc radiotracer, emitting 140.5 keV γ-rays inside the RF coil by the Bruker BioSpec 47/20 (4.7 T) MR animal scanner. For the evaluation of measured data, SPECT-back projection software was developed in Matlab. Our results pave the way for a preclinical MRI-SPECT insert system. This research was performed in the framework of the Medipix Collaboration

  • Czech name

  • Czech description

Classification

  • Type

    Jost - Miscellaneous article in a specialist periodical

  • CEP classification

  • OECD FORD branch

    30500 - Other medical sciences

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    European Journal of Physics

  • ISSN

    0143-0807

  • e-ISSN

    1361-6404

  • Volume of the periodical

    1662

  • Issue of the periodical within the volume

    012036

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    6

  • Pages from-to

    2-7

  • UT code for WoS article

  • EID of the result in the Scopus database

    2-s2.0-85096364592

Basic information

Result type

Jost - Miscellaneous article in a specialist periodical

Jost

OECD FORD

Other medical sciences

Year of implementation

2020