Significant Improvement of Biocompatibility of Polypropylene Mesh for Incisional Hernia Repair by Using Poly-?-Caprolactone Nanofibers Functionalized with Thrombocyte-Rich Solution

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21720%2F15%3A00232099" target="_blank" >RIV/68407700:21720/15:00232099 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21460/15:00232099
Result on the web
<a href="http://dx.doi.org/10.2147/IJN.S77816" target="_blank" >http://dx.doi.org/10.2147/IJN.S77816</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2147/IJN.S77816" target="_blank" >10.2147/IJN.S77816</a>

Result language
angličtina
Original language name
Significant Improvement of Biocompatibility of Polypropylene Mesh for Incisional Hernia Repair by Using Poly-?-Caprolactone Nanofibers Functionalized with Thrombocyte-Rich Solution
Original language description
Incisional hernia is the most common postoperative complication, affecting up to 20% of patients after abdominal surgery. Insertion of a synthetic surgical mesh has become the standard of care in ventral hernia repair. However, the implementation of a mesh does not reduce the risk of recurrence and the onset of hernia recurrence is only delayed by 2-3 years. Nowadays, more than 100 surgical meshes are available on the market, with polypropylene the most widely used for ventral hernia repair. Nonetheless, the ideal mesh does not exist yet; it still needs to be developed. Polycaprolactone nanofibers appear to be a suitable material for different kinds of cells, including fibroblasts, chondrocytes, and mesenchymal stem cells. The aim of the study reportedhere was to develop a functionalized scaffold for ventral hernia regeneration. We prepared a novel composite scaffold based on a polypropylene surgical mesh functionalized with poly-?-caprolactone (PCL) nanofibers and adhered thrombocyte
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EI - Biotechnology and bionics
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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